Medical Sciences Research

คณะวิทยาศาสตร์การแพทย์ มหาวิทยาลัยพะเยา
ซิงค์ข้อมูลล่าสุด: 31 ส.ค. 2569 - 14:56 น.
ย้อนกลับไปรายชื่อนักวิจัย
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ผศ.ดร. กฤษณะ คู่เทียม
Asst.prof. Dr. Krissana Khoothiam
Microbiology • สายวิชาการ • krissana.kh@up.ac.th
สาขาการวิจัย: Biochemistry, Genetics and Molecular Biology · 11 Medicine · 11
Scopus
24
ผลงานตีพิมพ์
First: 6 | Co: 18
221
Citations รวม
9
h-index
ภาพรวมความเชี่ยวชาญและคุณภาพผลงานวิจัย (Research Highlights & Impact)
คุณภาพวารสาร (Quartiles) Q1+Q2: 92%
Q1
14
Q2
8
Q3
1
Q4
1
ยึดตาม Scopus CiteScore
SDGs เชี่ยวชาญหลัก พบ 5 เป้าหมาย
3 การมีสุขภาพและความเป็นอยู่ที่ดี
24 เรื่อง
9 อุตสาหกรรม นวัตกรรม และโครงสร้างพื้นฐาน
11 เรื่อง
2 ขจัดความหิวโหย
4 เรื่อง
จำแนกตามพจนานุกรมคำสำคัญของคณะ
ดัชนีอ้างอิงสากล (NIH RCR) NIH iCite Benchmark
RCR เฉลี่ย
1.17
RCR สูงสุด
3.30
ได้รับการอ้างอิงสูงกว่าเกณฑ์เฉลี่ยโลก
เกณฑ์มาตรฐานโลก = 1.00 (NIH Benchmark)
เครือข่ายสากล & หัวข้อวิจัย
ประเทศร่วมวิจัยหลัก:
Germany (2)
หัวข้อวิจัยเด่น (OpenAlex):
MicroRNA in disease regulation
Natural Antidiabetic Agents Studies
การวิเคราะห์คลัสเตอร์สากล (OpenAlex Topics)
สถิติการอัปเดตผลงาน
รวม 20 ทุน
University of Phayao 7 ทุน
Chiang Mai University 3 ทุน
National Science and Technology Development Agency 2 ทุน
Otago School of Medical Sciences 2 ทุน
Thailand Science Research and Innovation 2 ทุน
Kasetsart University Research and Development Institute 1 ทุน
National Research Council of Thailand 1 ทุน
Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation, Thailand 1 ทุน
School of Medical Sciences, Universiti Sains Malaysia 1 ทุน
นับจากเลขทุน/รหัสทุนที่ไม่ซ้ำกันต่อแหล่งทุน ผลงานหลายชิ้นจากทุนก้อนเดียวกันจะนับเป็น 1 ทุน

รายการผลงานสิ่งตีพิมพ์ (24 รายการ)

Phytochemical profiling of Syzygium nervosum fruit pulp extracts and their modulatory effects on oxidative stress and cytokine production
ผู้แต่ง: Thepmalee C.
BMC Complementary Medicine and Therapies (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: School of Medical Sciences, Universiti Sains Malaysia (RSPG670029)
บทคัดย่อ (Abstract): Syzygium nervosum A. Cunn. ex DC., a plant traditionally used in Southeast Asian medicine, has recently gained scientific attention for its broad range of biological activities and health benefits, including anti-inflammatory, antimicrobial, and antitumor effects. In this study, we aim to compare...
scopus DOI: 10.1186/s12906-026-05269-7 Q1 Co-Author 3 SDG 3 (90%)
Antibacterial Mechanisms and Skin-Protective Activities of Syzygium nervosum Leaf Extracts from Different Geographical Origins
ผู้แต่ง: Khoothiam K.
International Journal of Molecular Sciences (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (2260/2568)
บทคัดย่อ (Abstract): Human skin is continuously exposed to microbial invasion and oxidative stress, highlighting the need for safe and effective natural skin-protective agents. This study aims to investigate the antibacterial, antioxidant, and anti-tyrosinase activities of methanolic leaf extracts of Syzygium nervosu...
scopus DOI: 10.3390/ijms27146515 Q1 First Author 3 SDG 3 (90%) 9 SDG 9 (60%)
Integrated nuclear rDNA, mitochondrial genome, and morphological characterization of minute intestinal fluke larvae (Plagiorchis sp.) from Phayao Province, Thailand
ผู้แต่ง: Japa O.
Acta Tropica (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (2260/2568)
บทคัดย่อ (Abstract): Minute intestinal flukes in the family Plagiorchiidae have received limited research attention, leading to a lack of molecular data and life cycle details. In this study, nuclear ribosomal DNA (rDNA), mitochondrial genome, and morphological analyses were integrated to characterize Plagiorchis spe...
scopus DOI: 10.1016/j.actatropica.2026.108070 Q2 Co-Author 3 SDG 3 (25%) 15 SDG 15 (15%)
Prevalence, Virulence Determinants, and Antimicrobial Resistance of Staphylococcus aureus and Escherichia coli Isolated from Computer Devices Used by Staff and Students at a Northern Thailand University
ผู้แต่ง: Upakut S.
Pathogens (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (2260/2568)
บทคัดย่อ (Abstract): Computer devices in university settings are frequently shared and repeatedly handled, making them potential reservoirs for pathogenic bacteria. This study aimed to investigate the prevalence, virulence determinants, and antimicrobial resistance profiles of Staphylococcus aureus and Escherichia co...
scopus DOI: 10.3390/pathogens15030274 Q1 Co-Author 3 SDG 3 (90%)
Molecular characterization of virulence and multidrug resistance in Escherichia coli isolated from houseflies (Musca domestica) at food markets in Northern Thailand
ผู้แต่ง: Khoothiam K.
Veterinary World (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (2260/2568)
บทคัดย่อ (Abstract): Background and aimHouseflies (Musca domestica) are recognized mechanical vectors of foodborne pathogens and antimicrobial-resistant bacteria, particularly in environments with intensive food-handling. Their role in disseminating virulent and multidrug-resistant (MDR) Escherichia coli at the food-...
scopus DOI: 10.14202/vetworld.2026.714-724 Q1 First Author 3 SDG 3 (89%) 12 SDG 12 (74%)
Design, Synthesis, and Antimicrobial Evaluation of Aryl Aziridines Bearing Electron-Withdrawing C-Substituents
ผู้แต่ง: Radtanajiravong L.
Pharmaceutical Chemistry Journal (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: National Science and Technology Development Agency (JRA-CO-2565-16970-TH)
บทคัดย่อ (Abstract): A series of 17 aryl aziridines bearing electron-withdrawing groups at the C1 position, including five novel compounds, were synthesized in moderate to excellent yields through thermal cycloaddition reactions of aryl azides and alkenes. All synthesized compounds were characterized using spectrosco...
scopus DOI: 10.1007/s11094-025-03454-5 Q4 Co-Author 3 SDG 3 (85%)
Lactic Acid Bacteria from Northern Thai (Lanna) Fermented Foods: A Promising Source of Probiotics with Applications in Synbiotic Formulation
ผู้แต่ง: Suwannasom N.
Foods (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (1862/2567)
บทคัดย่อ (Abstract): Northern Thai culture offers a rich variety of traditional fermented foods beneficial for gastrointestinal health. In this study, we characterized lactic acid bacteria (LAB) from various indigenous fermented foods as potential probiotic candidates and determined their properties for application i...
scopus DOI: 10.3390/foods14020244 Q1 Co-Author 3 SDG 3 (85%) 2 SDG 2 (60%)
α-Mangostin enhances cisplatin activity in drug-resistant breast cancer cells by targeting multidrug resistance-associated protein 2
ผู้แต่ง: Thepmalee C.
Journal of Applied Pharmaceutical Science (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (5081/2567)
บทคัดย่อ (Abstract): Cisplatin resistance presents a significant challenge in breast cancer treatment, often resulting in therapy failure and relapse. The overexpression of multidrug resistance-associated protein (MRP) in breast cancer cells contributes to chemotherapy resistance. Combining cisplatin with other anti-...
scopus DOI: 10.7324/JAPS.2025.232471 Q2 Co-Author 3 SDG 3 (98%) 9 SDG 9 (41%)
Probiotic encapsulation in CaCO3 microparticles: Enhancement of viability under heat treatments and simulated gastrointestinal conditions
ผู้แต่ง: Khoothiam K.
Lwt (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (FF66-RIM056)
บทคัดย่อ (Abstract): The aim of this study was to evaluate the effect of microencapsulation on the viability and stability of Lactobacillus plantarum TISTR 543 using calcium carbonate microparticles (CaCO3-MPs) produced by co-precipitation. Free bacterial and encapsulated cells were freeze-dried with or without lacto...
scopus DOI: 10.1016/j.lwt.2024.117221 Q1 First Author 3 SDG 3 (85%) 2 SDG 2 (60%)
Enhancing cancer immunotherapy using cordycepin and Cordyceps militaris extract to sensitize cancer cells and modulate immune responses
ผู้แต่ง: Thepmalee C.
Scientific Reports (2024)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (RGNS 63–145)
บทคัดย่อ (Abstract): Integrating immunotherapy with natural compounds holds promise in enhancing the immune system’s ability to eliminate cancer cells. Cordyceps militaris, a traditional Chinese medicine, emerges as a promising candidate in this regard. This study investigates the effects of cordycepin and C. militar...
scopus DOI: 10.1038/s41598-024-72833-x Q1 Co-Author 3 SDG 3 (95%) 9 SDG 9 (70%) RCR 3.30 · เปอร์เซ็นไทล์ 86
Comprehensive phytochemical profiling and biological activities of Hodgsonia heteroclita subsp. indochinensis seed extracts
ผู้แต่ง: Thepmalee C.
Heliyon (2024)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation, Thailand (FF66-RIM048)
บทคัดย่อ (Abstract): Hodgsonia heteroclita subsp. indochinensis, a member of the Cucurbitaceae family, is utilized in traditional medicinal remedies based on indigenous wisdom. This study aimed to comprehensively identify and analyze the bioactive phytoconstituents within H. heteroclita subsp. indochinensis seeds. Se...
scopus DOI: 10.1016/j.heliyon.2024.e36686 Q1 Co-Author 3 SDG 3 (85%) 9 SDG 9 (50%) RCR 0.72 · เปอร์เซ็นไทล์ 39
Prevalence, antimicrobial resistance, and enterotoxin gene profiles of Staphylococcus aureus isolated from mobile phones of the food vendors in Phayao province, Thailand
ผู้แต่ง: Khoothiam K.
Annals of Clinical Microbiology and Antimicrobials (2023)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (FF64-RIM038)
บทคัดย่อ (Abstract): Background: Mobile phones are widely used and may cause bacterial pathogens to spread among various professionals. Staphylococcus aureus from the mobile phones can contaminate the hands of food vendors and food during the cooking or packaging process. This research aimed to determine the prevalen...
scopus DOI: 10.1186/s12941-023-00621-y Q1 First Author 3 SDG 3 (90%) 2 SDG 2 (60%) RCR 1.08 · เปอร์เซ็นไทล์ 53
Efficacy and safety of nanoparticle albumin-bound paclitaxel in advanced non-small cell lung cancer: A systematic review and meta-analysis of clinical trials and observational studies
ผู้แต่ง: Suwannasom N.
Heliyon (2023)
ประเทศร่วมวิจัย: Germany, Thailand
แหล่งทุนวิจัย: University of Phayao (UoE62010)
บทคัดย่อ (Abstract): BackgroundThe efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) in advanced non-small cell lung cancer (NSCLC) have yielded inconsistent findings.Materials and methodsWe conducted a systematic review and meta-analysis, including comparative and noncomparative trials an...
scopus DOI: 10.1016/j.heliyon.2023.e21903 Q1 Co-Author 3 SDG 3 (97%) 9 SDG 9 (41%) RCR 0.43 · เปอร์เซ็นไทล์ 26
Anti-cancer effect of a phytochemical compound – 7R-acetylmelodorinol – against triple-negative breast cancer cells
ผู้แต่ง: Thepmalee C.
Biomedicine and Pharmacotherapy (2023)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (RGNS 63-145)
บทคัดย่อ (Abstract): Triple-negative breast cancer (TNBC) is a highly aggressive subtype currently lacking effective treatment options. Consequently, novel and effective drugs or compounds are urgently needed to treat TNBC. Therefore, this study aimed to evaluate the potential of 7R-acetylmelodorinol (7R-AMDL), a phy...
scopus DOI: 10.1016/j.biopha.2023.115286 Q1 Co-Author 3 SDG 3 (96%) 9 SDG 9 (41%) RCR 0.80 · เปอร์เซ็นไทล์ 43
Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study
ผู้แต่ง: Suwannasom N.
Beilstein Journal of Nanotechnology (2023)
ประเทศร่วมวิจัย: Germany, Thailand
แหล่งทุนวิจัย: University of Phayao (FF64-RIB006)
บทคัดย่อ (Abstract): Curcumin (CUR), a polyphenolic compound, shows promising biological properties, particularly antioxidant activity. However, its medical applications are limited due to its low water solubility, bioavailability, and pH-instability. CUR-loaded albumin microparticles (CUR-HSA-MPs) of submicron size ...
scopus DOI: 10.3762/BJNANO.14.93 Q2 Co-Author 3 SDG 3 (85%) 9 SDG 9 (40%) RCR 0.88 · เปอร์เซ็นไทล์ 46
Screening and characterization of antioxidant, anti-aging, and anti-microbial activity of herbal extracts
ผู้แต่ง: Khonthun C.
Functional Foods in Health and Disease (2023)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Otago School of Medical Sciences (MS 221006)
บทคัดย่อ (Abstract): Aging is a process caused by oxidants and aging-related enzymes. Therefore, the inhibition of these processes can exacerbate anti-aging agents. This study aimed to evaluate the antioxidant and anti-aging activities of leaf extracts from seven herbs used in traditional Thai herbal remedies. Method...
scopus DOI: 10.31989/ffhd.v13i2.1070 Q2 Co-Author 3 SDG 3 (85%) 12 SDG 12 (60%)
Evaluation of Anti-Hyperglycemia and Complications of Red and Black Thai Jasmine Rice Cultivars in Streptozotocin-Induced Diabetic Rats
ผู้แต่ง: Suwannasom N.
Molecules (2022)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (104062)
บทคัดย่อ (Abstract): The phytochemical constituents of red (RR) and black (BR) rice extracts were determined using high-pressure liquid chromatography (HPLC). Phytochemical screening revealed the presence of catechin, rutin, isoquercetin, cyanidin 3-glucoside, cyanidin 3-O-rutinoside, peonidin and quercetin. The anti...
scopus DOI: 10.3390/molecules27228043 Q1 Co-Author 3 SDG 3 (90%) 2 SDG 2 (30%) RCR 0.89 · เปอร์เซ็นไทล์ 46
High prevalence of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates: A 5-year retrospective study at a Tertiary Hospital in Northern Thailand
ผู้แต่ง: Siriphap A.
Frontiers in Cellular and Infection Microbiology (2022)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Otago School of Medical Sciences (MS 201003)
บทคัดย่อ (Abstract): Background: The global emergence and spread of extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales, especially Escherichia coli and Klebsiella pneumoniae, have been recognized as a public health concern as severe infections caused by these microorganisms increase morbidity and mort...
scopus DOI: 10.3389/fcimb.2022.955774 Q1 Co-Author 3 SDG 3 (90%) RCR 3.10 · เปอร์เซ็นไทล์ 85
Effect of ethanolic extract from Piper sarmentosum on antihyperglycemic activity and complications in normal and streptozotocin-induced diabetic rats
ผู้แต่ง: Suwannasom N.
Journal of Applied Pharmaceutical Science (2022)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (FF64-RIB006)
บทคัดย่อ (Abstract): The antihyperglycemic effect of ethanolic extract of Piper sarmentosum leaves (PSE) on diabetes and its complications was evaluated in streptozotocin-induced diabetic rats. Seventy-two Wistar albino rats (n = 72) were randomly distributed into six groups (n = 12 per group), namely control, normal...
scopus DOI: 10.7324/JAPS.2022.120408 Q2 Co-Author 3 SDG 3 (95%)
Isothermal detection of lncRNA using T7 RNA polymerase mediated amplification coupled with fluorescence-based sensor
ผู้แต่ง: Khoothiam K.
Analytical Biochemistry (2021)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: National Science and Technology Development Agency (P1750034)
บทคัดย่อ (Abstract): In this study, the isothermal detection of a cervical cancer-associated long non-coding RNA (lncRNA), namely, lncRNA-ATB, was performed for the first time with high selectivity and sensitivity via a T7 RNA polymerase transcription-mediated amplification system combined with a graphene oxide (GO) ...
scopus DOI: 10.1016/j.ab.2021.114212 Q2 First Author 3 SDG 3 (90%) 9 SDG 9 (60%) RCR 0.56 · เปอร์เซ็นไทล์ 32
Antibacterial Activity of Acorus calamus Linn. and Litsea cubeba (Lour.) Pers. and Their Efficacy in Shower Gel Formulation
ผู้แต่ง: Chaiwaree S.
Tropical Journal of Natural Product Research (2021)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (UPSP-IRTC 63/005)
บทคัดย่อ (Abstract): Acorus calamus and Litsea cubeba are known to have antibacterial properties. This research aimed to evaluate the anti-acne activity of A. calamus and L. cubeba against acne bacteria and to develop a shower gel. The antibacterial activity of the extracts was assessed by disc-diffusion method. The ...
scopus DOI: 10.26538/tjnpr/v5i12.7 Q3 Co-Author 3 SDG 3 (96%) 12 SDG 12 (42%)
Ultrasensitive detection of lung cancer-associated miRNAs by multiple primer-mediated rolling circle amplification coupled with a graphene oxide fluorescence-based (MPRCA-GO) sensor
ผู้แต่ง: Khoothiam K.
Analyst (2019)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: National Science and Technology Development Agency (P1750034)
บทคัดย่อ (Abstract): MicroRNAs (miRNAs) play important roles in gene regulation and have been reported as biomarkers in cancer diagnosis. Herein, we develop an isothermal miRNA detection platform based on the highly efficient, multiple primer-mediated rolling circle amplification method coupled with a graphene oxide-...
scopus DOI: 10.1039/c9an00517j Q1 First Author 3 SDG 3 (96%) 9 SDG 9 (64%) RCR 1.19 · เปอร์เซ็นไทล์ 56
Rolling circle amplification and graphene-based sensor-on-a-chip for sensitive detection of serum circulating miRNAs
ผู้แต่ง: Treerattrakoon K.
Analytical Biochemistry (2019)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Kasetsart University Research and Development Institute
บทคัดย่อ (Abstract): In this study, we developed a simple multiplex miRNA detection platform based on rolling circle amplification and the fluorescence quenching property of reduced graphene oxide. The detection platform could be applied on a microfluidics chip with a mobile system controller to eliminate contaminati...
scopus DOI: 10.1016/j.ab.2019.04.016 Q2 Co-Author 3 SDG 3 (90%) 9 SDG 9 (70%) RCR 1.10 · เปอร์เซ็นไทล์ 54
A single-step polymerase chain reaction for simultaneous detection and differentiation of nontypeable and serotypeable Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae
ผู้แต่ง: Kunthalert D.
International Journal of Pediatric Otorhinolaryngology (2013)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: National Research Council of Thailand
บทคัดย่อ (Abstract): Objective: The critically high prevalence of bacterial otitis media worldwide has prompted a proper disease management. While vaccine development for otitis media is promising, the reliable and effective methods for diagnosis of such etiologic agents are of importance. Methods: We developed a mul...
scopus DOI: 10.1016/j.ijporl.2012.11.019 Q2 Co-Author 3 SDG 3 (90%) 9 SDG 9 (50%) RCR 0.05 · เปอร์เซ็นไทล์ 4