รศ.ดร. กนกกาญจน์ พรหมน้อย
Assoc.Prof.Dr. Kanokkarn Phromnoi
สาขาการวิจัย:
Medicine · 20
Biochemistry, Genetics and Molecular Biology · 16
24
ผลงานตีพิมพ์
First: 9
|
Co: 15
1144
Citations รวม
15
h-index
ภาพรวมความเชี่ยวชาญและคุณภาพผลงานวิจัย (Research Highlights & Impact)
คุณภาพวารสาร (Quartiles)
Q1+Q2: 92%
Q1
10
Q2
12
Q3
1
Q4
0
ยึดตาม Scopus CiteScore
ไม่มี Q: 1
SDGs เชี่ยวชาญหลัก
พบ 5 เป้าหมาย
24 เรื่อง
10 เรื่อง
4 เรื่อง
จำแนกตามพจนานุกรมคำสำคัญของคณะ
ดัชนีอ้างอิงสากล (NIH RCR)
NIH iCite Benchmark
RCR เฉลี่ย
1.97
RCR สูงสุด
6.16
ได้รับการอ้างอิงสูงกว่าเกณฑ์เฉลี่ยโลก
เกณฑ์มาตรฐานโลก = 1.00 (NIH Benchmark)
เครือข่ายสากล & หัวข้อวิจัย
ประเทศร่วมวิจัยหลัก:
United States (11)
India (2)
South Korea (1)
หัวข้อวิจัยเด่น (OpenAlex):
การวิเคราะห์คลัสเตอร์สากล (OpenAlex Topics)
รายการผลงานสิ่งตีพิมพ์ (24 รายการ)
Genetic and transcriptomic alterations underlying aggressiveness in 5-fluorouracil-resistant HCT116 cells
Medical Oncology (2025)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (MD66-03)
บทคัดย่อ (Abstract): Resistance to 5-fluorouracil (5-FU) remains an obstacle to effective colorectal cancer (CRC) treatment. Genetic alterations play significant roles in the development of drug-induced chemoresistance, leading to tumor recurrence and increased aggressiveness. This study sought to characterize the tr...
Anthocyanins from a new hybrid sweet potato peel cultivated in Northern Thailand mitigate LPS-induced inflammation and RANKL-induced osteoporosis by regulating ROS-mediated pathways
Inflammopharmacology (2025)
ประเทศร่วมวิจัย:
Thailand, South Korea
Thailand, South Korea
แหล่งทุนวิจัย: University of Phayao (FF66-RIM063)
บทคัดย่อ (Abstract): Maejo 341 Sweet potato (MSP) is a new purple sweet potato variety cultivated in Northern Thailand, but its health benefits are unknown. This study aimed to investigate its antioxidant, anti-inflammatory, and anti-osteoporotic activities, as well as its anthocyanin content. The peel and flesh of M...
Effects of Pogonatherum paniceum (Lamk) Hack extract on anti-mitochondrial DNA mediated inflammation by attenuating Tlr9 expression in LPS-induced macrophages
Nutrition Research and Practice (2023)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao (RD61067)
บทคัดย่อ (Abstract): BACKGROUND/OBJECTIVES: Mitochondrial DNA leakage leads to inflammatory responses via endosome activation. This study aims to evaluate whether the perennial grass water extract (Pogonatherum panicum) ameliorate mitochondrial DNA (mtDNA) leakage. MATERIALS/METHODS: The major bioactive constituents ...
Comparative analysis of bioactive-phytochemical characteristics, antioxidants activities, and anti-inflammatory properties of selected black rice germ and bran (Oryza sativa L.) varieties
European Food Research and Technology (2023)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Chiang Mai University (9/2022)
บทคัดย่อ (Abstract): Black rice has numerous health benefits and one of the well-known functional foods throughout the world. To encourage the increasing trend of the consumer interest in health-promoting functional foods, special varieties of rice have been developed offering greater nutrient values and exhibiting b...
Screening and characterization of antioxidant, anti-aging, and anti-microbial activity of herbal extracts
Functional Foods in Health and Disease (2023)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Otago School of Medical Sciences (MS 221006)
บทคัดย่อ (Abstract): Aging is a process caused by oxidants and aging-related enzymes. Therefore, the inhibition of these processes can exacerbate anti-aging agents. This study aimed to evaluate the antioxidant and anti-aging activities of leaf extracts from seven herbs used in traditional Thai herbal remedies. Method...
Anti‐Inflammatory Effects of Red Rice Bran Extract Ameliorate Type I Interferon Production via STING Pathway
Foods (2022)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Otago School of Medical Sciences (FF64‐ RIM039)
บทคัดย่อ (Abstract): Type I interferons (IFNs‐I) are inflammatory cytokines that play an essential role in the pathogenesis of inflammation and autoimmune diseases. Signaling through nucleic acid sensors causes the production of IFNs‐I. A stimulator of interferon genes (STING) is a DNA sensor that signals transductio...
Anti-Osteoporosis Effect of Perilla frutescens Leaf Hexane Fraction through Regulating Osteoclast and Osteoblast Differentiation
Molecules (2022)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (103949)
บทคัดย่อ (Abstract): Osteoporosis is the result of an imbalance in the bone-remodeling process via an increase in osteoclastic activity and a decrease in osteoblastic activity. Our previous studies have shown that Perilla frutescens seed meal has anti-osteoclastogenic activity. However, the role of perilla leaf hexan...
Inhibitory effect of a rosmarinic acid-enriched fraction prepared from nga-mon (Perilla frutescens) seed meal on osteoclastogenesis through the rank signaling pathway
Antioxidants (2021)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Chiang Mai University (FF64-UoE043)
บทคัดย่อ (Abstract): The aim of this study is to determine antioxidant and anti-inflammatory activities relating to the antiosteoporosis effects of various perilla seed meal (PSM) fractions. The remaining waste of perilla seed obtained from cold oil compression was extracted with 70% ethanol and sequentially fraction...
Anti-inflammatory and antioxidant activities of medicinal plants used by traditional healers for antiulcer treatment
Scientia Pharmaceutica (2019)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Thailand Research Fund (RD59051)
บทคัดย่อ (Abstract): For centuries, many kinds of native plants and their products have been used for the treatment of gastric ulcers by traditional healers in Phayao province. The current study aimed to investigate the polyphenol content in some of these medicinal plants and to point out the relationship between the...
Polyphenols and Rosmarinic acid Contents, Antioxidant and Anti-Inflammatory Activities of Different Solvent Fractions from Nga-Mon (Perilla frutescens) Leaf
Journal of Pharmacy and Nutrition Sciences (2019)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Thailand Research Fund (MRG5980170)
บทคัดย่อ (Abstract): Perilla is a rich source of polyphenols, which exhibits antioxidant, anti-inflammatory activities, and a variety of biological effects. The effect of differential solvents on the polyphenols, flavonoids, rosmarinic acid (RA), antiinflammatory and antioxidant activities of perilla leaf require inv...
Correction: Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax (Journal of Biological Chemistry (2011) 286 (1134-1146))
Journal of Biological Chemistry (2016)
ประเทศร่วมวิจัย:
Thailand
Thailand
บทคัดย่อ (Abstract): Nimbolide Sensitizes Human Colon Cancer Cells to TRAIL through Reactive Oxygen Species- and ERK-dependent Up-regulation of Death Receptors, p53, and BaxJournal of Biological ChemistryVol. 286Issue 2PreviewTNF-related apoptosis-inducing ligand (TRAIL) shows promise as a cancer treatment, but acqui...
Erratum: A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents (Molecular Pharmacology (2010) 79 (279-289))
Molecular Pharmacology (2016)
ประเทศร่วมวิจัย:
Thailand
Thailand
บทคัดย่อ (Abstract): Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-κB (NF-...
Chronic diseases caused by chronic inflammation require chronic treatment: The anti-inflammatory lifestyle
Inflammation Lifestyle and Chronic Diseases the Silent Link (2016)
ประเทศร่วมวิจัย:
United States, Thailand
United States, Thailand
บทคัดย่อ (Abstract): Every second an American has at least one chronic illness, and 60 million Americans suffer from multiple chronic conditions. According to some studies, despite advances in modern medicine, our health is worse today than ever before in our history. In the year 2000, the U.S. population was 276 mil...
Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
Biochemical Pharmacology (2013)
ประเทศร่วมวิจัย:
United States, Thailand
United States, Thailand
บทคัดย่อ (Abstract): The major goal of cancer drug discovery is to find an agent that is safe and affordable, yet effective against cancer. Here we show that morin (3,5,7,2',4'-pentahydroxyflavone) has potential against cancer cells through suppression of the signal transducer and activator of transcription 3 (STAT3)...
Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: A new use for an old drug
British Journal of Pharmacology (2012)
ประเทศร่วมวิจัย:
United States, Thailand
United States, Thailand
แหล่งทุนวิจัย: National Cancer Institute (P30CA016672)
บทคัดย่อ (Abstract): BACKGROUND AND PURPOSE Most patients with cancer die not because of the tumour in the primary site, but because it has spread to other sites. Common tumours, such as breast, multiple myeloma, and prostate tumours, frequently metastasize to the bone. To search for an inhibitor of cancer-induced bo...
Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1
Molecular Pharmacology (2011)
ประเทศร่วมวิจัย:
United States, Thailand
United States, Thailand
แหล่งทุนวิจัย: National Cancer Institute (P01CA124787)
บทคัดย่อ (Abstract): Because constitutive activation of signal transducers and activators of transcription-3 (STAT3) has been linked with cellular transformation, survival, proliferation, chemoresistance, and angiogenesis of various tumor cells, agents that can suppress STAT3 activation have potential as cancer thera...
Identification of novel anti-inflammatory agents from ayurvedic medicine for prevention of chronic diseases: "Reverse pharmacology" and "Bedside to bench" approach
Current Drug Targets (2011)
ประเทศร่วมวิจัย:
United States, Thailand
United States, Thailand
บทคัดย่อ (Abstract): Inflammation, although first characterized by Cornelius Celsus, a physician in first Century Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a link between inflammation and cancer, cardiovascular diseases, diabetes, pulmonary diseases, neurological diseases and...
Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax
Journal of Biological Chemistry (2011)
ประเทศร่วมวิจัย:
United States, India, Thailand
United States, India, Thailand
แหล่งทุนวิจัย: National Cancer Institute (P30CA016672)
บทคัดย่อ (Abstract): TNF-related apoptosis-inducing ligand (TRAIL) shows promise as a cancer treatment, but acquired tumor resistance to TRAIL is a roadblock. Here we investigated whether nimbolide, a limonoid, could sensitize human colon cancer cells to TRAIL. As indicated by assays that measure esterase activity, s...
A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents
Molecular Pharmacology (2011)
ประเทศร่วมวิจัย:
United States, Thailand
United States, Thailand
แหล่งทุนวิจัย: National Cancer Institute (P01CA124787)
บทคัดย่อ (Abstract): Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3′-dihydroxy-3,6,7,8,4′- pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-κB (NF...
Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer
Cancer Prevention Research (2010)
ประเทศร่วมวิจัย:
United States, India, Thailand
United States, India, Thailand
แหล่งทุนวิจัย: National Cancer Institute (P30CA016672)
บทคัดย่อ (Abstract): The discovery of new uses for older, clinically approved drugs is one way to expedite drug development for cancer. Thiocolchicoside, a semisynthetic colchicoside from the plant Gloriosa superba, is a muscle relaxant and used to treat rheumatologic and orthopedic disorders because of its analgesic...
A dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways
Anticancer Research (2010)
ประเทศร่วมวิจัย:
United States, Thailand
United States, Thailand
แหล่งทุนวิจัย: National Cancer Institute (P01CA124787)
บทคัดย่อ (Abstract): We sought to determine the molecular basis for the anticancer activities of 5,3′-dihydroxy-3,6,7,8,4′-penta-methoxyflavone (DH-PMF), isolated from Gardenia obtusifolia traditionally used in Thailand for a variety of ailments. As little as 1 μM DH-PMF inhibited the proliferation of prostate, colon...
Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer
Planta Medica (2010)
ประเทศร่วมวิจัย:
United States, Thailand
United States, Thailand
บทคัดย่อ (Abstract): Observational studies have suggested that lifestyle risk factors such as tobacco, alcohol, high-fat diet, radiation, and infections can cause cancer and that a diet consisting of fruits and vegetables can prevent cancer. Evidence from our laboratory and others suggests that agents either causing ...
Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway
Molecular Cancer Research (2010)
ประเทศร่วมวิจัย:
United States, Thailand
United States, Thailand
แหล่งทุนวิจัย: National Cancer Institute (P01CA124787)
บทคัดย่อ (Abstract): Most patients with cancer die not because of the tumor in the primary site, but because it has spread to other sites. Common tumors, such as breast, multiple myeloma, and prostate tumors, frequently metastasize to the bone. It is now well recognized that osteoclasts are responsible for the osteol...
Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids
Acta Pharmacologica Sinica (2009)
ประเทศร่วมวิจัย:
Thailand
Thailand
บทคัดย่อ (Abstract): Aim: Stromelysin 1 (matrix metalloproteinase 3; MMP-3) is an enzyme known to be involved in tumor invasion and metastasis. In this study, flavonoids from vegetables and fruits, such as quercetin, kaempferol, genistein, genistin, and daidzein, were tested for their ability to modulate the secretio...