รศ.ดร. คมศักดิ์ พินธะ
Assoc.Prof.Dr. Komsak Pintha
สาขาการวิจัย:
Medicine · 31
Biochemistry, Genetics and Molecular Biology · 18
39
ผลงานตีพิมพ์
First: 4
|
Co: 35
992
Citations รวม
18
h-index
ภาพรวมความเชี่ยวชาญและคุณภาพผลงานวิจัย (Research Highlights & Impact)
คุณภาพวารสาร (Quartiles)
Q1+Q2: 85%
Q1
17
Q2
16
Q3
3
Q4
1
ยึดตาม Scopus CiteScore
ไม่มี Q: 2
SDGs เชี่ยวชาญหลัก
พบ 5 เป้าหมาย
39 เรื่อง
13 เรื่อง
5 เรื่อง
จำแนกตามพจนานุกรมคำสำคัญของคณะ
ดัชนีอ้างอิงสากล (NIH RCR)
NIH iCite Benchmark
RCR เฉลี่ย
1.69
RCR สูงสุด
4.33
ได้รับการอ้างอิงสูงกว่าเกณฑ์เฉลี่ยโลก
เกณฑ์มาตรฐานโลก = 1.00 (NIH Benchmark)
เครือข่ายสากล & หัวข้อวิจัย
ประเทศร่วมวิจัยหลัก:
Brazil (2)
China (1)
Myanmar (1)
หัวข้อวิจัยเด่น (OpenAlex):
การวิเคราะห์คลัสเตอร์สากล (OpenAlex Topics)
รายการผลงานสิ่งตีพิมพ์ (39 รายการ)
Effect of Cooking on Chemical Constituents and In Vitro Anti-diabetes Properties of Red Rice
Natural and Life Sciences Communications (2025)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (FF66UoE020)
บทคัดย่อ (Abstract): Cooking red rice induces chemical and biological changes to the phytochemical content, affecting the food's texture and nutritional profile. In the present study, the effect of cooking red rice on its chemical contents and in vitro anti-diabetes properties was investigated. The raw red rice was e...
Assessing the Antioxidant, Hepatoprotective, and Iron-Chelating Potential of Perilla frutescens Seed
Biomedicines (2025)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (KREF186410)
บทคัดย่อ (Abstract): Background/Objectives: Iron overload is a serious condition that can increase the production of reactive oxygen species (ROS), leading to oxidative tissue damage and organ dysfunction. While current pharmaceutical drugs for iron chelation have limitations, the search for natural herbs with iron-c...
Evaluation of Phytoconstituents, Nutritional Quality, and In Vitro Biological Activities of Red Rice Ethanolic Extract from Different Regions of Chiang Rai and Phayao
Journal of Current Science and Technology (2025)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Agricultural Research Development Agency (FF66-UoE020)
บทคัดย่อ (Abstract): Red rice, a pigmented rice, is a staple food in Thailand that has beneficial biological properties for the consumer. The objective of this research was to assess the phytochemical composition, macro- and micro-nutritional quality, as well as the anti-glycation and in vitro antioxidant properties ...
Antioxidant and xanthine oxidase inhibitory activities of rosmarinic acid-rich extract from perilla seed meal
Scienceasia (2024)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao (RD62056)
บทคัดย่อ (Abstract): Hyperuricemia can lead to various diseases, including diabetes, renal disorders, and gout. Xanthine oxidase (XO), a crucial enzyme, synthesizes uric acid from xanthine; and concurrently generates reactive oxygen species, causing oxidative stress. This study aimed to validate the biological functi...
Cleistocalyx nervosum var. paniala mitigates oxidative stress and inflammation induced by PM10 soluble extract in trophoblast cells via miR-146a-5p
Scientific Reports (2024)
ประเทศร่วมวิจัย:
Thailand,
Brazil
Thailand,
Brazil
แหล่งทุนวิจัย: University of Phayao (FF66-RIM067)
บทคัดย่อ (Abstract): Air pollution poses a significant global concern, notably impacting pregnancy outcomes through mechanisms such as DNA damage, oxidative stress, inflammation, and altered miRNA expression, all of which can adversely affect trophoblast functions. Cleistocalyx nervosum var. paniala, known for its ab...
Neuroprotective effects of g-Aminobutyric acid-enriched germinated riceberry extract in cerebral ischemic reperfusion-induced cognitive impairment mice
Journal of Applied Pharmaceutical Science (2024)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao (631006)
บทคัดย่อ (Abstract): This study investigates the neuroprotective effects of riceberry (RB) and germinated riceberry (GRB) extracts on cognitive impairment induced by cerebral ischemia-reperfusion (IR) injury. Our findings indicate that the germination process reduces total phenolic content and total antioxidant capac...
Protective Effect of Perilla Seed Meal and Perilla Seed Extract against Dextran Sulfate Sodium-Induced Ulcerative Colitis through Suppressing Inflammatory Cytokines in Mice
Molecules (2024)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao (MS231004)
บทคัดย่อ (Abstract): An excessive inflammatory response of the gastrointestinal tract is recognized as one of the major contributors to ulcerative colitis (UC). Despite this, effective preventive approaches for UC remain limited. Rosmarinic acid (RA), an enriched fraction from Perilla frutescens, has been shown to ex...
Immunopeptidomics in the cancer immunotherapy era
Exploration of Targeted Anti Tumor Therapy (2024)
ประเทศร่วมวิจัย:
Thailand
Thailand
บทคัดย่อ (Abstract): Cancer is the primary cause of death worldwide, and conventional treatments are painful, complicated, and have negative effects on healthy cells. However, cancer immunotherapy has emerged as a promising alternative. Principle of cancer immunotherapy is the re-activation of T-cell to combat the tu...
Bioefficacy of Nga-Mon (Perilla frutescens) Fresh and Dry Leaf: Assessment of Antioxidant, Antimutagenicity, and Anti-Inflammatory Potential
Plants (2023)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Chiang Mai University (020-2564)
บทคัดย่อ (Abstract): Perilla leaves are known to be a rich source of polyphenols, which have been shown to exhibit various biological effects. This study aimed to compare the bioefficacies and bioactivities of fresh (PLEf) and dry (PLEd) Thai perilla (Nga-mon) leaf extracts. Phytochemical analysis indicated that both...
Protective Effect of Red Rice Extract Rich in Proanthocyanidins in a Murine Colitis Model
Biomedicines (2023)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao (FF65-RIM117)
บทคัดย่อ (Abstract): Inflammatory bowel disease (IBD) has become a global concern. Proanthocyanidin-rich red rice extract (PRRE) has been shown to suppress the inflammatory response in cellular cultures. However, the anti-colitis effect of PRRE has never been investigated in animals. This study aimed to examine the p...
Effects of Drinking Coconut Water on Circulatory and Respiratory Function and Post-Workout Recovery in Long Distance Runners
8th International Conference on Digital Arts Media and Technology and 6th Ecti Northern Section Conference on Electrical Electronics Computer and Telecommunications Engineering Ecti Damt and Ncon 2023 (2023)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao (PBTSC63001)
บทคัดย่อ (Abstract): The physiological variables of drinking coconut water compared to plain water (2 ml per kg of body weight) in running mini-marathons$(\mathbf{N}=6)$and half-marathons$(\mathbf{N}=6)$. The results show that the average running time and recovery time of the mini-marathon volunteers who drank coconu...
In Vitro anti-metastasis of Perilla frutescens leaf water extract on aggressive human breast cancer cells
Journal of Associated Medical Sciences (2022)
ประเทศร่วมวิจัย:
Thailand,
China,
Myanmar
Thailand,
China,
Myanmar
แหล่งทุนวิจัย: University of Phayao (RSC64015)
บทคัดย่อ (Abstract): Background: Perilla frutescens is a long-established plant that is often used in foods and traditional medicines in Asian countries. The perilla leaf contains a considerable number of bioactive substances, such as phenolics and flavonoids, which have been demonstrated to possess anticancer activi...
Protective effect of Perilla leaf extract against ROS formation and inflammation induced by TNF-α in A549 human lung carcinoma cell line
Songklanakarin Journal of Science and Technology (2022)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Office of the Higher Education Commission (FF64-UoE019)
บทคัดย่อ (Abstract): Perilla frutescens is an herb traditionally used to treat chronic diseases owing to its antioxidant and anti-inflammatory properties. This study aimed to determine the antioxidant and anti-inflammatory effects of perilla leaf extract (PLE) in TNF--treated A549 human lung carcinoma cell line. Peri...
The Effects of Synbiotics Administration on Stress-Related Parameters in Thai Subjects—A Preliminary Study
Foods (2022)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao (2561)
บทคัดย่อ (Abstract): Urbanization influences our lifestyle, especially in fast-paced environments where we are more prone to stress. Stress management is considered advantageous in terms of longevity. The use of probiotics for psychological treatment has a small amount of diverse proven evidence to support this. Howe...
Anti-Osteoporosis Effect of Perilla frutescens Leaf Hexane Fraction through Regulating Osteoclast and Osteoblast Differentiation
Molecules (2022)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (103949)
บทคัดย่อ (Abstract): Osteoporosis is the result of an imbalance in the bone-remodeling process via an increase in osteoclastic activity and a decrease in osteoblastic activity. Our previous studies have shown that Perilla frutescens seed meal has anti-osteoclastogenic activity. However, the role of perilla leaf hexan...
Anti-aging effect of polyphenols: possibilities and challenges
Plant Bioactives as Natural Panacea Against Age Induced Diseases Nutraceuticals and Functional Lead Compounds for Drug Development (2022)
ประเทศร่วมวิจัย:
Thailand
Thailand
บทคัดย่อ (Abstract): Polyphenols are a large and diverse group of natural compounds occurring in plants. Polyphenols are chemically characterized by multiple phenol units, including flavonoids, catechins, ellagic acid, and anthocyanins. Most polyphenols can reduce the generation of free radicals, reactive oxygen spec...
PM10 Alters Trophoblast Cell Function and Modulates miR-125b-5p Expression
Biomed Research International (2022)
ประเทศร่วมวิจัย:
Thailand,
Brazil
Thailand,
Brazil
แหล่งทุนวิจัย: Office of the Higher Education Commission (MS632001)
บทคัดย่อ (Abstract): Air pollution is one of the largest global environmental health hazards that threaten premature mortality or morbidity. Particulate matter 10 (PM10) has been demonstrated to contribute to several human diseases via dysregulated miRNA expression. Trophoblast cells play a key role in implantation a...
Molecular mechanism of antioxidant and anti-inflammatory effects of omega-3 fatty acids in perilla seed oil and rosmarinic acid rich fraction extracted from perilla seed meal on TNF-α induced A549 lung adenocarcinoma cells
Molecules (2021)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Office of the Higher Education Commission (FF64-UoE019)
บทคัดย่อ (Abstract): Industrially, after the removal of oil from perilla seeds (PS) by screw-type compression, the large quantities of residual perilla seed meal (PSM) becomes non-valuable waste. Therefore, to increase the health value and price of PS and PSM, we focused on the biological effects of perilla seed oil ...
Anti-inflammatory effect of Perilla frutescens seed oil rich in omega-3 fatty acid on dextran sodium sulfate-induced colitis in mice
Research in Pharmaceutical Sciences (2021)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Thailand Research Fund (621009)
บทคัดย่อ (Abstract): Background and purpose: Ulcerative colitis is a chronic inflammatory bowel disease that involves diffused inflammation of the large intestine. Omega-3 fatty acid (FA) has been known to regulate the inflammatory response associated with ulcerative colitis pathogenesis. Perilla frutescens is a valu...
Potential probiotic enterococcus faecium OV3-6 and its bioactive peptide as alternative bio-preservation
Foods (2021)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Chiang Mai University (PHD56I0037)
บทคัดย่อ (Abstract): Probiotic Enterococcus faecium OV3-6 and its secreted active peptide were characterized and investigated. The strain survived in simulated gastric and small intestinal conditions at 88.16% and 94.33%, respectively. The safety assessment revealed that the strain was shown α-hemolysis and susceptib...
The Attenuation of TNF-α-mediated Inflammatory Responses in Human Lung Adenocarcinoma Cell Line by Perilla Seed and Seed Meal Extract
Chiang Mai University Journal of Natural Sciences (2021)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Office of the Higher Education Commission (FF64-UoE019)
บทคัดย่อ (Abstract): Thai perilla (Perilla frutescens) extracts, which contain a substantial quantity of bioactive substances including phenolics and flavonoids, have shown marked anti-inflammatory activities in several investigated models. In the present study, the effect of perilla seed extract (PSE) and seed meal ...
Perilla seed oil alleviates gut dysbiosis, intestinal inflammation and metabolic disturbance in obese-insulin-resistant rats
Nutrients (2021)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Office of the Higher Education Commission (MRG6280240)
บทคัดย่อ (Abstract): Background: High-fat diet (HFD) consumption induced gut dysbiosis, inflammation, obese-insulin resistance. Perilla seed oil (PSO) is a rich source of omega-3 polyunsaturated fatty acids with health promotional effects. However, the effects of PSO on gut microbiota/inflammation and metabolic distu...
Suppressive effects of rosmarinic acid rich fraction from perilla on oxidative stress, inflammation and metastasis ability in A549 cells exposed to PM via C-jun, P-65-Nf-Kb and akt signaling pathways
Biomolecules (2021)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Office of the Higher Education Commission (MRG6180080)
บทคัดย่อ (Abstract): Particulate matter from forest fires (PMFF) is an environmental pollutant causing oxidative stress, inflammation, and cancer cell metastasis due to the presence of polycyclic aromatic hydrocarbons (PAHs). Perilla seed meal contains high levels of polyphenols, including rosmarinic acid (RA). The a...
Collagenase and melanogenesis inhibitory effects of perilla frutescens pomace extract and its efficacy in topical cosmetic formulations
Cosmetics (2020)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao (RD61051)
บทคัดย่อ (Abstract): In previous studies, Perilla frutescens pomace was shown to contain bioactive phenolic compounds and good anti-oxidative activity. However, reports about collagenase activity and melanogenesis inhibitory effects of P. frutescens pomace are limited. This study aimed to evaluate the bioactivity of ...
Inhibitory effect of perilla frutescens l. Leaves extract on melanogenesis and skin whitening efficacy in the underarm whitening product application
Key Engineering Materials (2020)
ประเทศร่วมวิจัย:
United Kingdom,
Thailand
United Kingdom,
Thailand
แหล่งทุนวิจัย: University of Phayao
บทคัดย่อ (Abstract): The effect of Perilla frutescens L. leaves extract (PFLE) on melanogenesis regulation in B16F10 cells was investigated. The extract had a significant inhibitory effect on melanogenesis in a dose-dependent manner without cytotoxicity at concentrations between 2.5 and 10 μg/mL. The PFLE was formula...
Alpha-linolenic acid content and expression of KASII and FAD3 in perilla seed associated with altitude of cultivation areas
Scienceasia (2019)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Agricultural Research Development Agency
บทคัดย่อ (Abstract): Perilla frutescens is commonly used as an n-3-fatty acid source for people living in Northern Thailand. However, cultivated areas are limited because it apparently requires specific growth conditions. Our results suggested that perilla seeds grown at higher altitude in Maehongson province contain...
The Innovation of Functional Foods in Asia: Iffa 2018
Asia Pacific Journal of Clinical Nutrition (2019)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao
บทคัดย่อ (Abstract): Functional foods (FF) are commonly consumed by Asians, and this trend has increased in recent years. Despite the reported health benefits of FF, it is necessary scrutiny and updates of the underpinning research are important. The first international conference on functional food innovation in Asi...
Rosmarinic Acid Enriched Fraction from Perilla frutescens Leaves Strongly Protects Indomethacin-Induced Gastric Ulcer in Rats
Biomed Research International (2019)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Thailand Research Fund (MRG5908128)
บทคัดย่อ (Abstract): Gastric ulcers are a common problem in upper gastrointestinal tract (GI) disorders. Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most aggressive factors leading to inducing gastric ulcers. Natural products with lower toxicity and safety are currently sought as a potential source t...
Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal
Journal of Food Biochemistry (2018)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Agricultural Research Development Agency (CRP5605021680)
บทคัดย่อ (Abstract): The objective of this study was to investigate the in vitro bioactivities associated with the content of phytochemicals in the extracts from perilla seed meal extract (PSME) compared with dietary seed (PSE). PSE had higher total phenolics and flavonoids content than PSME. However, hydrophilic phy...
Thai perilla (Perilla frutescens) leaf extract inhibits human breast cancer invasion and migration
Maejo International Journal of Science and Technology (2018)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao
บทคัดย่อ (Abstract): Thai perilla (Perilla frutescens), also called Nga-mon, contains a substantial quantity of bioactive substances including phenolics and flavonoids. These phytochemicals have been linked to various bioactivities of P. frutescens such as in vitro and in vivo anti-inflammatory, anti-oxidative and an...
The effect of Perilla frutescens leaf on 1, 2-dimethylhydrazine-induced initiation of colon carcinogenesis in rats
Journal of Food Biochemistry (2018)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Agricultural Research Development Agency
บทคัดย่อ (Abstract): In this study, the chemopreventive properties of Perilla frutescens leaf extract (PLE) on rat colon carcinogenesis were investigated during initiation and postinitiation stages. Rats were fed orally by 50 and 500 mg/kg bw of PLE continuously from 1 week before subcutaneously injection of 1,2-dime...
Anti-hyperglycaemic and anti-hyperlipidaemic effects of black and red rice in streptozotocin-induced diabetic rats
Scienceasia (2017)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phoenix
บทคัดย่อ (Abstract): Increasing numbers of diabetic patients, especially those with type II, can link their condition to changes in eating habits. Black rice and red rice are not only a source of carbohydrate but also rich sources of antioxidants, especially proanthocyanidins and anthocyanins. This study determines t...
Learning and memory enhancing effects of anthocyanin in black rice extract on cerebral ischaemia in mice
Scienceasia (2015)
ประเทศร่วมวิจัย:
Thailand
Thailand
บทคัดย่อ (Abstract): The protective effect of anthocyanins extracted from black rice against learning and memory impairment was investigated in mice. In a Morris water maze test, mice with transient cerebral ischaemia required a longer time to find the hidden platform than the sham-operated controls. Daily treatment ...
Proanthocyanidin in red rice inhibits MDA-MB-231 breast cancer cell invasion via the expression control of invasive proteins
Biological and Pharmaceutical Bulletin (2015)
ประเทศร่วมวิจัย:
Thailand
Thailand
บทคัดย่อ (Abstract): Proanthocyanidin is one of the main active compounds found in red jasmine rice. We previously reported that red rice extract could reduce cancer cell invasion. However, the direct effect of proanthocyanidin from red rice on the invasion of cancer cells and the exact molecular mechanism remained u...
Anti-invasive activity against cancer cells of phytochemicals in red jasmine rice (Oryza sativa L.)
Asian Pacific Journal of Cancer Prevention (2014)
ประเทศร่วมวิจัย:
Thailand
Thailand
บทคัดย่อ (Abstract): Red rice contains pharmacological substances including phenolics, oryzanol, tocotrienol and tocopherol. Recently, red rice extract has been employed as a source of antioxidants for inhibition of tumor growth. This study was carried out to evaluate the anti-invasion effects of red rice extract fra...
Inhibition of P-glycoprotein mediated multidrug resistance by stemofoline derivatives
Chemical and Pharmaceutical Bulletin (2013)
ประเทศร่วมวิจัย:
Australia,
Thailand
Australia,
Thailand
บทคัดย่อ (Abstract): Resistance to chemotherapy in cancer patients has been correlated to the overexpression of the ATPbinding cassette (ABC) drug transporters including P-glycoprotein (P-gp) that actively efflux chemotherapeutic drugs from cancer cells. We examined the mutidrug resistance reversing property of stemo...
Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance
Journal of Nutritional Biochemistry (2012)
ประเทศร่วมวิจัย:
United States,
Thailand
United States,
Thailand
แหล่งทุนวิจัย: National Cancer Institute (ZIABC010030)
บทคัดย่อ (Abstract): Multidrug resistance (MDR) is a major factor in the failure of chemotherapy in cancer patients. Resistance to chemotherapy has been correlated to the overexpression of ABC drug transporters including P-glycoprotein (P-gp) that actively efflux chemotherapeutic drugs from cancer cells. Our previous...
Inhibition of P-glycoprotein function and expression by kaempferol and quercetin
Journal of Chemotherapy (2005)
ประเทศร่วมวิจัย:
Thailand
Thailand
บทคัดย่อ (Abstract): The 170 kDa plasma membrane P-glycoprotein (Pgp) causes the efflux of chemotherapeutic drugs from cells and is believed to be an important mechanism in multidrug resistance (MDR) in human cancer. This study demonstrates that some putative flavonoids, i.e., flavonols (quercetin and kaempferol) and...
Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract
Cancer Chemotherapy and Pharmacology (2004)
ประเทศร่วมวิจัย:
Thailand
Thailand
บทคัดย่อ (Abstract): Purpose: Multidrug resistance (MDR) is known as a problem limiting the success of therapy in patients treated long term with chemotherapeutic drugs. The drug resistance is mainly due to the overexpression of the 170 kDa P-glycoprotein (Pgp), which causes a reduction in drug accumulation in the ca...