รศ.ดร. วิทยา ชัยวังเย็น
Assoc.Prof.Dr. Wittaya Chaiwangyen
สาขาการวิจัย:
Medicine · 27
Biochemistry, Genetics and Molecular Biology · 15
32
ผลงานตีพิมพ์
First: 8
|
Co: 24
1343
Citations รวม
16
h-index
ภาพรวมความเชี่ยวชาญและคุณภาพผลงานวิจัย (Research Highlights & Impact)
คุณภาพวารสาร (Quartiles)
Q1+Q2: 94%
Q1
19
Q2
11
Q3
0
Q4
1
ยึดตาม Scopus CiteScore
ไม่มี Q: 1
SDGs เชี่ยวชาญหลัก
พบ 5 เป้าหมาย
32 เรื่อง
5 เรื่อง
4 เรื่อง
จำแนกตามพจนานุกรมคำสำคัญของคณะ
ดัชนีอ้างอิงสากล (NIH RCR)
NIH iCite Benchmark
RCR เฉลี่ย
2.31
RCR สูงสุด
7.50
ได้รับการอ้างอิงสูงกว่าเกณฑ์เฉลี่ยโลก
เกณฑ์มาตรฐานโลก = 1.00 (NIH Benchmark)
เครือข่ายสากล & หัวข้อวิจัย
ประเทศร่วมวิจัยหลัก:
Germany (14)
Brazil (7)
China (1)
หัวข้อวิจัยเด่น (OpenAlex):
การวิเคราะห์คลัสเตอร์สากล (OpenAlex Topics)
รายการผลงานสิ่งตีพิมพ์ (32 รายการ)
Renoprotective Potential of Beetroot Spent Extract Under Hyperglycemic Conditions
Foods (2026)
ประเทศร่วมวิจัย:
Thailand, China
Thailand, China
แหล่งทุนวิจัย: National Research Council of Thailand
บทคัดย่อ (Abstract): Diabetic nephropathy is a major complication of diabetes mellitus, primarily driven by hyperglycemia-induced oxidative stress and renal tubular cell injury. Beetroot (Beta vulgaris L.) is rich in antioxidant phytochemicals, and its industrial processing generates large amounts of spent material t...
Protective Role of Rosmarinic Acid–Enriched Elsholtzia kachinensis Extract Against Oxidative and Inflammatory Stress in Human Trophoblasts Through the miR-138-5p/FOXC1 Pathway
Biochemistry Research International (2026)
ประเทศร่วมวิจัย:
Thailand, Brazil
Thailand, Brazil
แหล่งทุนวิจัย: Thailand Science Research and Innovation (N42A660433)
บทคัดย่อ (Abstract): Inflammation-induced dysregulation of microRNAs, particularly miR-138-5p, compromises trophoblast cell function and may contribute to pregnancy-related complications. While Elsholtzia species have been reported to possess therapeutic properties, the anti-inflammatory effects of Elsholtzia kachine...
MicroRNA expression in response to environmental hazards: Implications for health
Ecotoxicology and Environmental Safety (2025)
ประเทศร่วมวิจัย:
Thailand, Brazil
Thailand, Brazil
แหล่งทุนวิจัย: Thailand Science Research and Innovation (N42A660433)
บทคัดย่อ (Abstract): MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally and are increasingly recognized as sensitive biomarkers of environmental exposure. This review explores how various environmental hazards—including radiation, air pollutants, heavy metals, pesticides...
Phytochemical Screening and In Vitro Antioxidant and Anticancer Evaluation of Stem and Leaf Extracts of Cissampelos pareira L.
Mediators of Inflammation (2025)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao (253/2567)
บทคัดย่อ (Abstract): This study was conducted to investigate the phytochemical constituents, antioxidant capacity, and anticancer potential of aqueous, ethanolic, and hexane extracts derived from the leaves and stems of Cissampelos pareira L. (C. pareira L.). Proximate analysis revealed that the stems contained a hig...
Antioxidant and xanthine oxidase inhibitory activities of rosmarinic acid-rich extract from perilla seed meal
Scienceasia (2024)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao (RD62056)
บทคัดย่อ (Abstract): Hyperuricemia can lead to various diseases, including diabetes, renal disorders, and gout. Xanthine oxidase (XO), a crucial enzyme, synthesizes uric acid from xanthine; and concurrently generates reactive oxygen species, causing oxidative stress. This study aimed to validate the biological functi...
Cleistocalyx nervosum var. paniala mitigates oxidative stress and inflammation induced by PM10 soluble extract in trophoblast cells via miR-146a-5p
Scientific Reports (2024)
ประเทศร่วมวิจัย:
Thailand, Brazil
Thailand, Brazil
แหล่งทุนวิจัย: University of Phayao (FF66-RIM067)
บทคัดย่อ (Abstract): Air pollution poses a significant global concern, notably impacting pregnancy outcomes through mechanisms such as DNA damage, oxidative stress, inflammation, and altered miRNA expression, all of which can adversely affect trophoblast functions. Cleistocalyx nervosum var. paniala, known for its ab...
Bioefficacy of Nga-Mon (Perilla frutescens) Fresh and Dry Leaf: Assessment of Antioxidant, Antimutagenicity, and Anti-Inflammatory Potential
Plants (2023)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Chiang Mai University (020-2564)
บทคัดย่อ (Abstract): Perilla leaves are known to be a rich source of polyphenols, which have been shown to exhibit various biological effects. This study aimed to compare the bioefficacies and bioactivities of fresh (PLEf) and dry (PLEd) Thai perilla (Nga-mon) leaf extracts. Phytochemical analysis indicated that both...
Anti-aging effect of polyphenols: possibilities and challenges
Plant Bioactives as Natural Panacea Against Age Induced Diseases Nutraceuticals and Functional Lead Compounds for Drug Development (2022)
ประเทศร่วมวิจัย:
Thailand
Thailand
บทคัดย่อ (Abstract): Polyphenols are a large and diverse group of natural compounds occurring in plants. Polyphenols are chemically characterized by multiple phenol units, including flavonoids, catechins, ellagic acid, and anthocyanins. Most polyphenols can reduce the generation of free radicals, reactive oxygen spec...
PM10 Alters Trophoblast Cell Function and Modulates miR-125b-5p Expression
Biomed Research International (2022)
ประเทศร่วมวิจัย:
Thailand, Brazil
Thailand, Brazil
แหล่งทุนวิจัย: Office of the Higher Education Commission (MS632001)
บทคัดย่อ (Abstract): Air pollution is one of the largest global environmental health hazards that threaten premature mortality or morbidity. Particulate matter 10 (PM10) has been demonstrated to contribute to several human diseases via dysregulated miRNA expression. Trophoblast cells play a key role in implantation a...
Molecular mechanism of antioxidant and anti-inflammatory effects of omega-3 fatty acids in perilla seed oil and rosmarinic acid rich fraction extracted from perilla seed meal on TNF-α induced A549 lung adenocarcinoma cells
Molecules (2021)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Office of the Higher Education Commission (FF64-UoE019)
บทคัดย่อ (Abstract): Industrially, after the removal of oil from perilla seeds (PS) by screw-type compression, the large quantities of residual perilla seed meal (PSM) becomes non-valuable waste. Therefore, to increase the health value and price of PS and PSM, we focused on the biological effects of perilla seed oil ...
Suppressive effects of rosmarinic acid rich fraction from perilla on oxidative stress, inflammation and metastasis ability in A549 cells exposed to PM via C-jun, P-65-Nf-Kb and akt signaling pathways
Biomolecules (2021)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Office of the Higher Education Commission (MRG6180080)
บทคัดย่อ (Abstract): Particulate matter from forest fires (PMFF) is an environmental pollutant causing oxidative stress, inflammation, and cancer cell metastasis due to the presence of polycyclic aromatic hydrocarbons (PAHs). Perilla seed meal contains high levels of polyphenols, including rosmarinic acid (RA). The a...
Doxorubicin induces cytotoxicity and miR-132 expression in granulosa cells
Reproductive Toxicology (2020)
ประเทศร่วมวิจัย:
Germany, Thailand
Germany, Thailand
แหล่งทุนวิจัย: Wilhelm Sander-Stiftung
บทคัดย่อ (Abstract): Doxorubicin (DOX) is one of the most commonly used drugs for the treatment of childhood cancers, including leukemia and lymphomas. Despite the high survival rate, female leukemia survivors are at higher risk of ovarian failure and infertility later in life. Treatment with chemotherapeutic drugs l...
MiR-519d-3p in trophoblastic cells: Effects, targets and transfer to allogeneic immune cells via extracellular vesicles
International Journal of Molecular Sciences (2020)
ประเทศร่วมวิจัย:
Germany, Thailand
Germany, Thailand
แหล่งทุนวิจัย: Deutscher Akademischer Austauschdienst (Ma1550/12-1)
บทคัดย่อ (Abstract): Members of the placenta-specific miRNA cluster C19MC, including miR-519d, are secreted by fetal trophoblast cells within extracellular vesicles (EVs). Trophoblast-derived EVs can be internalized by the autologous trophoblast and surrounding maternal immune cells, resulting in coordination of cell...
Identification of miRNAs and associated pathways regulated by Leukemia Inhibitory Factor in trophoblastic cell lines
Placenta (2019)
ประเทศร่วมวิจัย:
Germany, 
Mexico, Thailand
Germany, Mexico, Thailand
แหล่งทุนวิจัย: Deutscher Akademischer Austauschdienst (MA 5082/7–1)
บทคัดย่อ (Abstract): Introduction: Leukemia Inhibitory Factor (LIF) regulates behavior of trophoblast cells and their interaction with immune and endothelial cells. In vitro, trophoblast cell response to LIF may vary depending on the cell model. Reported differences in the miRNA profile of trophoblastic cells may be ...
Alpha-linolenic acid content and expression of KASII and FAD3 in perilla seed associated with altitude of cultivation areas
Scienceasia (2019)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Agricultural Research Development Agency
บทคัดย่อ (Abstract): Perilla frutescens is commonly used as an n-3-fatty acid source for people living in Northern Thailand. However, cultivated areas are limited because it apparently requires specific growth conditions. Our results suggested that perilla seeds grown at higher altitude in Maehongson province contain...
The Innovation of Functional Foods in Asia: Iffa 2018
Asia Pacific Journal of Clinical Nutrition (2019)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao
บทคัดย่อ (Abstract): Functional foods (FF) are commonly consumed by Asians, and this trend has increased in recent years. Despite the reported health benefits of FF, it is necessary scrutiny and updates of the underpinning research are important. The first international conference on functional food innovation in Asi...
Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal
Journal of Food Biochemistry (2018)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: Agricultural Research Development Agency (CRP5605021680)
บทคัดย่อ (Abstract): The objective of this study was to investigate the in vitro bioactivities associated with the content of phytochemicals in the extracts from perilla seed meal extract (PSME) compared with dietary seed (PSE). PSE had higher total phenolics and flavonoids content than PSME. However, hydrophilic phy...
Preventive effects of polyphenol-rich perilla leaves on oxidative stress and haemolysis
Scienceasia (2018)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao
บทคัดย่อ (Abstract): We investigated the effect of perilla leaf extract (PLE) containing polyphenols on various biological functions including antioxidant activity, iron chelation, and red blood cell haemolysis protection. The total phenolic and flavonoid content were determined by colorimetric assay and HPLC analysi...
Thai perilla (Perilla frutescens) leaf extract inhibits human breast cancer invasion and migration
Maejo International Journal of Science and Technology (2018)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phayao
บทคัดย่อ (Abstract): Thai perilla (Perilla frutescens), also called Nga-mon, contains a substantial quantity of bioactive substances including phenolics and flavonoids. These phytochemicals have been linked to various bioactivities of P. frutescens such as in vitro and in vivo anti-inflammatory, anti-oxidative and an...
Anti-hyperglycaemic and anti-hyperlipidaemic effects of black and red rice in streptozotocin-induced diabetic rats
Scienceasia (2017)
ประเทศร่วมวิจัย:
Thailand
Thailand
แหล่งทุนวิจัย: University of Phoenix
บทคัดย่อ (Abstract): Increasing numbers of diabetic patients, especially those with type II, can link their condition to changes in eating habits. Black rice and red rice are not only a source of carbohydrate but also rich sources of antioxidants, especially proanthocyanidins and anthocyanins. This study determines t...
PIM kinases 1, 2 and 3 in intracellular LIF signaling, proliferation and apoptosis in trophoblastic cells
Experimental Cell Research (2017)
ประเทศร่วมวิจัย:
Brazil, Germany, Thailand
Brazil, Germany, Thailand
แหล่งทุนวิจัย: Deutscher Akademischer Austauschdienst (A/09/97227)
บทคัดย่อ (Abstract): Proviral insertion in murine (PIM) lymphoma proteins are mainly regulated by the Janus Kinase/Signal Transducer Activator of Transcription (JAK/STAT) signaling pathway, which can be activated by members of the Interleukin-6 (IL-6) family, including Leukemia Inhibitory Factor (LIF). Aim of the stu...
Involvement of STAT1 in proliferation and invasiveness of trophoblastic cells
Reproductive Biology (2017)
ประเทศร่วมวิจัย:
Brazil, Germany, Thailand
Brazil, Germany, Thailand
แหล่งทุนวิจัย: Deutscher Akademischer Austauschdienst (MA 1550/12-1)
บทคัดย่อ (Abstract): Trophoblast proliferation and invasion are controlled by cytokines and growth factors present at the implantation site. Members of the Interleukin-6 (IL-6) family of cytokines trigger their effects through activation of intracellular cascades including the Janus Kinase/Signal Transducer and Activ...
MicroRNA-141 is upregulated in preeclamptic placentae and regulates trophoblast invasion and intercellular communication
Translational Research (2016)
ประเทศร่วมวิจัย:
Germany, Thailand
Germany, Thailand
แหล่งทุนวิจัย: Deutscher Akademischer Austauschdienst (MO 2017/3-1)
บทคัดย่อ (Abstract): Preeclampsia (PE) is one of the leading causes of maternal and perinatal morbidity and mortality worldwide. Abnormal expression of microRNAs (miRNAs) occurs in several pregnancy diseases including PE. Placental trophoblast cells express a specific set of miRNAs which changes during pregnancy. The...
Oncostatin M and leukaemia inhibitory factor trigger signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2 pathways but result in heterogeneous cellular responses in trophoblast cells
Reproduction Fertility and Development (2016)
ประเทศร่วมวิจัย:
Germany, Thailand
Germany, Thailand
บทคัดย่อ (Abstract): Leukaemia inhibitory factor (LIF) and oncostatin M (OSM) are pleiotropic cytokines present at the implantation site that are important for the normal development of human pregnancy. These cytokines share the cell membrane receptor subunit gp130, resulting in similar functions. The aim of this stu...
STAT5 is Activated by Epidermal Growth Factor and Induces Proliferation and Invasion in Trophoblastic Cells
Reproductive Sciences (2015)
ประเทศร่วมวิจัย:
Germany, Thailand
Germany, Thailand
แหล่งทุนวิจัย: Friedrich-Schiller-Universität Jena (MO 2017/3 -1)
บทคัดย่อ (Abstract): Epidermal growth factor (EGF) is expressed by decidual and trophoblast cells and influences manifold cellular functions during embryo implantation. Thus far, signaling of EGF via Signal Transducer and Activator of Transcription 5 (STAT5) has been only partially investigated. STAT5 stimulates prol...
Dissimilar microRNA-21 functions and targets in trophoblastic cell lines of different origin
International Journal of Biochemistry and Cell Biology (2015)
ประเทศร่วมวิจัย:
Germany, Thailand
Germany, Thailand
แหล่งทุนวิจัย: Deutscher Akademischer Austauschdienst (MO 2017/3-1)
บทคัดย่อ (Abstract): Trophoblast cells express a singular miRNA expression profile which varies during pregnancy and whose alteration may be associated with pregnancy complications. miR-21, a widely known oncomir, is highly expressed in human placenta but its role in regulating trophoblast cells remains unclear. The ...
Elsevier Trophoblast Research Award Lecture: Origin, evolution and future of placenta miRNAs
Placenta (2014)
ประเทศร่วมวิจัย:
Germany, Thailand
Germany, Thailand
บทคัดย่อ (Abstract): MicroRNAs (miRNAs) regulate the expression of a large number of genes in plants and animals. Placental miRNAs appeared late in evolution and can be found only in mammals. Nevertheless, these miRNAs are constantly under evolutionary pressure. As a consequence, miRNA sequences and their mRNA target...
Pregnancy-associated miRNA-clusters
Journal of Reproductive Immunology (2013)
ประเทศร่วมวิจัย:
Germany, Thailand
Germany, Thailand
แหล่งทุนวิจัย: Deutscher Akademischer Austauschdienst
บทคัดย่อ (Abstract): MicroRNAs (miRNAs) are expressed in the placenta and can be detected in maternal plasma. An increasing number of studies have been published on the cellular origin, distribution and function of miRNAs in pregnancy. Specific miRNA profiles have been described for the placenta, maternal plasma and ...
Intranuclear crosstalk between extracellular regulated kinase1/2 and signal transducer and activator of transcription 3 regulates JEG-3 choriocarcinoma cell invasion and proliferation
Scientific World Journal (2013)
ประเทศร่วมวิจัย:
Germany, Thailand
Germany, Thailand
บทคัดย่อ (Abstract): Invasiveness of trophoblast and choriocarcinoma cells is in part mediated via leukemia inhibitory factor- (LIF-) induced activation of signal transducer and activator of transcription 3 (STAT3). The regulation of STAT3 phosphorylation at its ser727 binding site, possible crosstalk with intracellu...
MicroRNA expression profiles of trophoblastic cells
Placenta (2012)
ประเทศร่วมวิจัย:
Germany, Thailand
Germany, Thailand
แหล่งทุนวิจัย: Deutscher Akademischer Austauschdienst (Ma1550/7-1)
บทคัดย่อ (Abstract): Background: MicroRNAs (miRNAs) are small single-stranded RNA molecules working as post-transcriptional modulators of gene expression. Trophoblast cells are a heterogenous group of fetal cells forming the feto-maternal interface and displaying a wide spectrum of functions. The regulation of their ...
Cytokines regulating trophoblast invasion
Advances in Neuroimmune Biology (2011)
ประเทศร่วมวิจัย:
Germany, 
Sweden, Brazil, 
United States, 
Colombia, 
Chile, 
Venezuela, 
India, 
Argentina, Thailand
Germany, Sweden, Brazil, United States, Colombia, Chile, Venezuela, India, Argentina, Thailand
บทคัดย่อ (Abstract): Pregnancy is personally special to every woman expecting a child, but is also interesting from the perspective of an immunologist. During a physiological pregnancy, the mother's immune system decides to tolerate and foster an incorporated, non-self, non-dangerous organism. Whether the maternal re...
Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA
Journal of Nutritional Biochemistry (2009)
ประเทศร่วมวิจัย:
Italy, Thailand
Italy, Thailand
แหล่งทุนวิจัย: National Research Council of Thailand
บทคัดย่อ (Abstract): Curcumin (Cur), a component of turmeric (Curcuma longa), has been reported to exhibit antimetastatic activities, but the mechanisms remain unclear. Other curcuminoids present in turmeric, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) have not been investigated whether they exhibit antim...