Medical Sciences Research

คณะวิทยาศาสตร์การแพทย์ มหาวิทยาลัยพะเยา
ซิงค์ข้อมูลล่าสุด: 31 ส.ค. 2569 - 14:56 น.
ย้อนกลับไปรายชื่อนักวิจัย
avatar
รศ.ดร. จุฑามาศ เทพมาลี
Assoc.Prof.Dr. Chutamas Thepmalee
Biochemistry • สายวิชาการ • chutamas.th@up.ac.th
สาขาการวิจัย: Medicine · 31 Biochemistry, Genetics and Molecular Biology · 22
Scopus
47
ผลงานตีพิมพ์
First: 9 | Co: 38
479
Citations รวม
12
h-index
ภาพรวมความเชี่ยวชาญและคุณภาพผลงานวิจัย (Research Highlights & Impact)
คุณภาพวารสาร (Quartiles) Q1+Q2: 91%
Q1
34
Q2
9
Q3
2
Q4
1
ยึดตาม Scopus CiteScore ไม่มี Q: 1
SDGs เชี่ยวชาญหลัก พบ 7 เป้าหมาย
3 การมีสุขภาพและความเป็นอยู่ที่ดี
47 เรื่อง
9 อุตสาหกรรม นวัตกรรม และโครงสร้างพื้นฐาน
24 เรื่อง
2 ขจัดความหิวโหย
5 เรื่อง
จำแนกตามพจนานุกรมคำสำคัญของคณะ
ดัชนีอ้างอิงสากล (NIH RCR) NIH iCite Benchmark
RCR เฉลี่ย
1.13
RCR สูงสุด
3.30
ได้รับการอ้างอิงสูงกว่าเกณฑ์เฉลี่ยโลก
เกณฑ์มาตรฐานโลก = 1.00 (NIH Benchmark)
เครือข่ายสากล & หัวข้อวิจัย
ประเทศร่วมวิจัยหลัก:
Germany (2) United Kingdom (2) United States (2)
หัวข้อวิจัยเด่น (OpenAlex):
Immunotherapy and Immune Responses
Ginger and Zingiberaceae research
การวิเคราะห์คลัสเตอร์สากล (OpenAlex Topics)
สถิติการอัปเดตผลงาน
รวม 41 ทุน
University of Phayao 11 ทุน
Chiang Mai University 10 ทุน
Thailand Science Research and Innovation 5 ทุน
Mahidol University 3 ทุน
Thailand Research Fund 2 ทุน
Chulalongkorn University 1 ทุน
Faculty of Medicine Siriraj Hospital, Mahidol University 1 ทุน
National Research Council of Thailand 1 ทุน
National Science and Technology Development Agency 1 ทุน
Newton Fund 1 ทุน
Office of the Higher Education Commission 1 ทุน
Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation, Thailand 1 ทุน
Otago School of Medical Sciences 1 ทุน
School of Medical Sciences, Universiti Sains Malaysia 1 ทุน
Stanford University 1 ทุน
นับจากเลขทุน/รหัสทุนที่ไม่ซ้ำกันต่อแหล่งทุน ผลงานหลายชิ้นจากทุนก้อนเดียวกันจะนับเป็น 1 ทุน

รายการผลงานสิ่งตีพิมพ์ (47 รายการ)

Phytochemical profiling of Syzygium nervosum fruit pulp extracts and their modulatory effects on oxidative stress and cytokine production
ผู้แต่ง: Thepmalee C.
BMC Complementary Medicine and Therapies (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: School of Medical Sciences, Universiti Sains Malaysia (RSPG670029)
บทคัดย่อ (Abstract): Syzygium nervosum A. Cunn. ex DC., a plant traditionally used in Southeast Asian medicine, has recently gained scientific attention for its broad range of biological activities and health benefits, including anti-inflammatory, antimicrobial, and antitumor effects. In this study, we aim to compare...
scopus DOI: 10.1186/s12906-026-05269-7 Q1 First Author 3 SDG 3 (90%)
Harnessing a bispecific αGD2 × αCD3 protein engager to target GD2-overexpressing lung tumors
ผู้แต่ง: Sawasdee N.
Scientific Reports (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (MS 251001)
บทคัดย่อ (Abstract): Lung cancer remains one of the most prevalent and lethal malignancies worldwide, with persistently poor 5-year survival rates across all stages. The development of novel therapies is therefore crucial for overcoming treatment resistance, improving survival rates, reducing side effects, and enhanc...
scopus DOI: 10.1038/s41598-026-42885-2 Q1 Co-Author 3 SDG 3 (97%) 9 SDG 9 (60%)
13-epi-manoyl oxide diterpenoids from the rhizomes of Kaempferia udonensis with anti-inflammatory activity
ผู้แต่ง: Chokchaisiri R.
Phytochemistry (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (2285)
บทคัดย่อ (Abstract): Eight previously undescribed 13- epi -manoyl oxide diterpenoids, designated udonensins A–H ( 1 – 8 ), were isolated from the rhizomes of Kaempferia udonensis . Their structures were elucidated based on 1D, 2D NMR, IR and HR-ESI-MS spectral data analysis, followed by electronic circular dichroism ...
scopus DOI: 10.1016/j.phytochem.2026.114899 Q1 Co-Author 3 SDG 3 (85%)
Three new diterpenoids from the rhizomes of Kaempferia minuta and their nitric oxide inhibitory effects
ผู้แต่ง: Kaisoda A.
Fitoterapia (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (2285)
บทคัดย่อ (Abstract): A phytochemical investigation of the rhizomes of Kaempferia minuta led to the isolation of eleven diterpenoids, including three new compounds, designated minutins A–C ( 1 – 3 ). Their structures were elucidated by comprehensive spectroscopic analyses (IR, HRESIMS, 1D/2D NMR) together with electro...
scopus DOI: 10.1016/j.fitote.2026.107278 Q1 Co-Author 3 SDG 3 (82%)
Antibacterial Mechanisms and Skin-Protective Activities of Syzygium nervosum Leaf Extracts from Different Geographical Origins
ผู้แต่ง: Khoothiam K.
International Journal of Molecular Sciences (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (2260/2568)
บทคัดย่อ (Abstract): Human skin is continuously exposed to microbial invasion and oxidative stress, highlighting the need for safe and effective natural skin-protective agents. This study aims to investigate the antibacterial, antioxidant, and anti-tyrosinase activities of methanolic leaf extracts of Syzygium nervosu...
scopus DOI: 10.3390/ijms27146515 Q1 Co-Author 3 SDG 3 (90%) 9 SDG 9 (60%)
Particulate matter exposure negatively affects the cancer immunosurveillance through PD-L1 upregulation and dendritic cell maturation suppression
ผู้แต่ง: Panya A.
Journal of Environmental Sciences China (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (FF-026/2567)
บทคัดย่อ (Abstract): The relationship between particulate matter (PM) pollution exposure and lung cancer incidence has been well established. However, the association between PM exposure and immunosurveillance, which indirectly controls tumor growth and progression, remains limited. In this study, we investigated the...
scopus DOI: 10.1016/j.jes.2025.09.069 Q1 Co-Author 3 SDG 3 (90%) 13 SDG 13 (60%)
Prevalence, Virulence Determinants, and Antimicrobial Resistance of Staphylococcus aureus and Escherichia coli Isolated from Computer Devices Used by Staff and Students at a Northern Thailand University
ผู้แต่ง: Upakut S.
Pathogens (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (2260/2568)
บทคัดย่อ (Abstract): Computer devices in university settings are frequently shared and repeatedly handled, making them potential reservoirs for pathogenic bacteria. This study aimed to investigate the prevalence, virulence determinants, and antimicrobial resistance profiles of Staphylococcus aureus and Escherichia co...
scopus DOI: 10.3390/pathogens15030274 Q1 Co-Author 3 SDG 3 (90%)
Molecular characterization of virulence and multidrug resistance in Escherichia coli isolated from houseflies (Musca domestica) at food markets in Northern Thailand
ผู้แต่ง: Khoothiam K.
Veterinary World (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (2260/2568)
บทคัดย่อ (Abstract): Background and aimHouseflies (Musca domestica) are recognized mechanical vectors of foodborne pathogens and antimicrobial-resistant bacteria, particularly in environments with intensive food-handling. Their role in disseminating virulent and multidrug-resistant (MDR) Escherichia coli at the food-...
scopus DOI: 10.14202/vetworld.2026.714-724 Q1 Co-Author 3 SDG 3 (89%) 12 SDG 12 (74%)
Aquilaria Crassna Pierre Ex Lecomte Leaf Extract Induces Apoptosis and Immunogenic Cell Death in Breast Cancer Cells, Enhancing Anti-Tumor Effects of Dendritic Cells
ผู้แต่ง: Pho-On P.
Trends in Sciences (2026)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Mahidol University (CB-61-006-04)
บทคัดย่อ (Abstract): Aquilaria crassna (A. crassna) Pierre ex Lecomte, commonly known as agarwood, is traditionally used in medicinal preparations. Previous studies suggest anti-cancer properties in A. crassna leaf extract but the mechanisms and its involvement in immunogenic cell death (ICD) remain unexplored. This ...
scopus DOI: 10.48048/tis.2026.11528 Q2 Co-Author 3 SDG 3 (98%) 9 SDG 9 (22%)
Genetic and transcriptomic alterations underlying aggressiveness in 5-fluorouracil-resistant HCT116 cells
ผู้แต่ง: Sooksaen P.
Medical Oncology (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (MD66-03)
บทคัดย่อ (Abstract): Resistance to 5-fluorouracil (5-FU) remains an obstacle to effective colorectal cancer (CRC) treatment. Genetic alterations play significant roles in the development of drug-induced chemoresistance, leading to tumor recurrence and increased aggressiveness. This study sought to characterize the tr...
scopus DOI: 10.1007/s12032-025-03078-5 Q1 Co-Author 3 SDG 3 (95%) 9 SDG 9 (40%)
Design, Synthesis, and Antimicrobial Evaluation of Aryl Aziridines Bearing Electron-Withdrawing C-Substituents
ผู้แต่ง: Radtanajiravong L.
Pharmaceutical Chemistry Journal (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: National Science and Technology Development Agency (JRA-CO-2565-16970-TH)
บทคัดย่อ (Abstract): A series of 17 aryl aziridines bearing electron-withdrawing groups at the C1 position, including five novel compounds, were synthesized in moderate to excellent yields through thermal cycloaddition reactions of aryl azides and alkenes. All synthesized compounds were characterized using spectrosco...
scopus DOI: 10.1007/s11094-025-03454-5 Q4 Co-Author 3 SDG 3 (85%)
Tacca chantrieri Rhizome Extract Induces Apoptosis and Inhibits Colony Formation and Migration in Triple-Negative, HER2+, and ER+ Breast Cancer Cell Lines
ผู้แต่ง: Thewaanukhor S.
Trends in Sciences (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: National Research Council of Thailand (N42A660849)
บทคัดย่อ (Abstract): Breast cancer is the most common cancer in females worldwide, and standard chemotherapy often causes significant side effects. Tacca chantrieri, a plant used in traditional medicine, contains bioactive compounds with anti-cancer properties. This study aimed to evaluate the anti-cancer activity of...
scopus DOI: 10.48048/tis.2025.10525 Q2 Co-Author 3 SDG 3 (96%) 9 SDG 9 (42%)
Atractylodes lancea Crude Extract Suppresses Triple-Negative Breast Cancer Metastasis via NF-kB signaling Pathway Inhibition
ผู้แต่ง: Changtong A.
Asian Pacific Journal of Cancer Prevention (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Mahidol University (CB-61-006-04)
บทคัดย่อ (Abstract): ObjectiveTriple-negative breast cancer (TNBC) is an aggressive subtype characterized by poor prognosis, high recurrence rates, and limited targeted therapies, often leading to metastasis in the brain, bones, lungs, and liver. The NF-kB signaling pathway plays a crucial role in TNBC metastasis. Ho...
scopus DOI: 10.31557/APJCP.2025.26.9.3369 Q2 Co-Author 3 SDG 3 (97%) 9 SDG 9 (34%)
Enhancing T cell cytotoxicity against lung cancer with an αPD-L1 protein engager and gemcitabine combination therapy
ผู้แต่ง: Thepmalee C.
Biomedicine and Pharmacotherapy (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Faculty of Medicine Siriraj Hospital, Mahidol University (FF039/2567)
บทคัดย่อ (Abstract): The overexpression of programmed cell death ligand 1 (PD-L1), a critical immune checkpoint protein, is associated with poor prognosis and reduced survival in lung cancer patients. Monoclonal antibodies targeting the PD-1/PD-L1 axis have been approved to disrupt this interaction and prevent immune...
scopus DOI: 10.1016/j.biopha.2025.118161 Q1 First Author 3 SDG 3 (98%) 9 SDG 9 (62%)
Enhancing T cell cytotoxicity in multiple myeloma with bispecific αPD-L1 × αCD3 T cell engager-armed T cells and low-dose bortezomib therapy
ผู้แต่ง: Sawasdee N.
Biomedicine and Pharmacotherapy (2025)
ประเทศร่วมวิจัย: Japan, Thailand
แหล่งทุนวิจัย: Mahidol University (N34E670096)
บทคัดย่อ (Abstract): Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by frequent relapse due to acquired treatment resistance, underscoring the need for innovative therapies, particularly for relapsed cases. This study explores the effects of low-dose bortezomib (BTZ) on programmed death li...
scopus DOI: 10.1016/j.biopha.2025.117878 Q1 Co-Author 3 SDG 3 (97%) 9 SDG 9 (45%)
A Comparative Study of Melittins from Apis florea and Apis mellifera as Cytotoxic Agents Against Non-Small Cell Lung Cancer (NSCLC) Cells and Their Combination with Gefitinib
ผู้แต่ง: Sattayawat P.
International Journal of Molecular Sciences (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (FF039/67)
บทคัดย่อ (Abstract): Lung cancer remains one of the most lethal malignancies, often diagnosed at advanced stages, leading to limited treatment options. Thus, identifying natural products with potent anti-cancer activity is crucial for improving treatment outcomes. While the melittin from Apis mellifera (Mel-AM) has b...
scopus DOI: 10.3390/ijms26062498 Q1 Co-Author 3 SDG 3 (98%) 9 SDG 9 (41%)
Lactic Acid Bacteria from Northern Thai (Lanna) Fermented Foods: A Promising Source of Probiotics with Applications in Synbiotic Formulation
ผู้แต่ง: Suwannasom N.
Foods (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (1862/2567)
บทคัดย่อ (Abstract): Northern Thai culture offers a rich variety of traditional fermented foods beneficial for gastrointestinal health. In this study, we characterized lactic acid bacteria (LAB) from various indigenous fermented foods as potential probiotic candidates and determined their properties for application i...
scopus DOI: 10.3390/foods14020244 Q1 Co-Author 3 SDG 3 (85%) 2 SDG 2 (60%)
α-Mangostin enhances cisplatin activity in drug-resistant breast cancer cells by targeting multidrug resistance-associated protein 2
ผู้แต่ง: Thepmalee C.
Journal of Applied Pharmaceutical Science (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (5081/2567)
บทคัดย่อ (Abstract): Cisplatin resistance presents a significant challenge in breast cancer treatment, often resulting in therapy failure and relapse. The overexpression of multidrug resistance-associated protein (MRP) in breast cancer cells contributes to chemotherapy resistance. Combining cisplatin with other anti-...
scopus DOI: 10.7324/JAPS.2025.232471 Q2 First Author 3 SDG 3 (98%) 9 SDG 9 (41%)
Probiotic encapsulation in CaCO3 microparticles: Enhancement of viability under heat treatments and simulated gastrointestinal conditions
ผู้แต่ง: Khoothiam K.
Lwt (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (FF66-RIM056)
บทคัดย่อ (Abstract): The aim of this study was to evaluate the effect of microencapsulation on the viability and stability of Lactobacillus plantarum TISTR 543 using calcium carbonate microparticles (CaCO3-MPs) produced by co-precipitation. Free bacterial and encapsulated cells were freeze-dried with or without lacto...
scopus DOI: 10.1016/j.lwt.2024.117221 Q1 Co-Author 3 SDG 3 (85%) 2 SDG 2 (60%)
Phytochemical Screening and In Vitro Antioxidant and Anticancer Evaluation of Stem and Leaf Extracts of Cissampelos pareira L.
ผู้แต่ง: Thim-uam A.
Mediators of Inflammation (2025)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (253/2567)
บทคัดย่อ (Abstract): This study was conducted to investigate the phytochemical constituents, antioxidant capacity, and anticancer potential of aqueous, ethanolic, and hexane extracts derived from the leaves and stems of Cissampelos pareira L. (C. pareira L.). Proximate analysis revealed that the stems contained a hig...
scopus DOI: 10.1155/mi/7555073 Q1 Co-Author 3 SDG 3 (88%) 2 SDG 2 (45%)
Abietane Diterpenoids from the Rhizomes of Kaempferia roscoeana and Their Anti-Inflammatory Activities
ผู้แต่ง: Chokchaisiri R.
Journal of Natural Products (2024)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (263/2567)
บทคัดย่อ (Abstract): Six new abietane diterpenes, roscoeananes A-F (1-6), along with two known compounds (7-8) were isolated from the rhizomes of Kaempferia roscoeana. The structures of all compounds were elucidated by analysis of spectroscopic data, and the absolute configurations were assigned by a comparison of th...
scopus DOI: 10.1021/acs.jnatprod.4c01127 Q1 Co-Author 3 SDG 3 (85%) RCR 1.64 · เปอร์เซ็นไทล์ 67
Enhancing cancer immunotherapy using cordycepin and Cordyceps militaris extract to sensitize cancer cells and modulate immune responses
ผู้แต่ง: Thepmalee C.
Scientific Reports (2024)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (RGNS 63–145)
บทคัดย่อ (Abstract): Integrating immunotherapy with natural compounds holds promise in enhancing the immune system’s ability to eliminate cancer cells. Cordyceps militaris, a traditional Chinese medicine, emerges as a promising candidate in this regard. This study investigates the effects of cordycepin and C. militar...
scopus DOI: 10.1038/s41598-024-72833-x Q1 First Author 3 SDG 3 (95%) 9 SDG 9 (70%) RCR 3.30 · เปอร์เซ็นไทล์ 86
Polysaccharide extract of Spirulina sp. increases effector immune-cell killing activities against cholangiocarcinoma
ผู้แต่ง: Panya A.
Plos One (2024)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University
บทคัดย่อ (Abstract): Cyanobacteria and algae serving as promising food supplements have recently garnered attention for their emerging potential in anti-cancer activity. Cholangiocarcinoma (CCA) or bile duct cancer is one of the top-leading cancers affecting people, particularly in Asian continent. With patients exhi...
scopus DOI: 10.1371/journal.pone.0312414 Q1 Co-Author 3 SDG 3 (95%) RCR 0.64 · เปอร์เซ็นไทล์ 36
Comprehensive phytochemical profiling and biological activities of Hodgsonia heteroclita subsp. indochinensis seed extracts
ผู้แต่ง: Thepmalee C.
Heliyon (2024)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation, Thailand (FF66-RIM048)
บทคัดย่อ (Abstract): Hodgsonia heteroclita subsp. indochinensis, a member of the Cucurbitaceae family, is utilized in traditional medicinal remedies based on indigenous wisdom. This study aimed to comprehensively identify and analyze the bioactive phytoconstituents within H. heteroclita subsp. indochinensis seeds. Se...
scopus DOI: 10.1016/j.heliyon.2024.e36686 Q1 First Author 3 SDG 3 (85%) 9 SDG 9 (50%) RCR 0.72 · เปอร์เซ็นไทล์ 39
Potent Cytotoxicity and Nitric Oxide Suppression of Compounds Derived from Kaempferia elegans Rhizomes: Molecular Modeling on EGFR Inhibition
ผู้แต่ง: Savaspun K.
Records of Natural Products (2024)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Thailand Science Research and Innovation (FF66-RIM015)
บทคัดย่อ (Abstract): A new naturally occurring diarylheptanoid, (1E,4Z,6E)-5-hydroxy-1,7-diphenylhepta-1,4,6-trien-3-one (3), was isolated from the rhizomes of K. elegans along with six known compounds, flavokawain B (1), 5,6-dehydrokawain (2), pinocembrin (4), cardamonin (5), alpinetin (6), and crotepoxide (7), amon...
scopus DOI: 10.25135/rnp.472.2406.3250 Q2 Co-Author 3 SDG 3 (92%) 9 SDG 9 (55%)
A new oligostilbenoid isolated from the stems of Ochna integerrima
ผู้แต่ง: Chokchaisiri R.
Phytochemistry Letters (2024)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (PBTSC66044)
บทคัดย่อ (Abstract): Integerrimol A (1), a new oligostilbenoid, along with six known compounds (2–7), was isolated and characterized from the stems of Ochna integerrima. The structure of compound 1 was established through extensive spectroscopic analysis. Furthermore, the absolute configuration of compound 1 was dete...
scopus DOI: 10.1016/j.phytol.2023.12.001 Q2 Co-Author 3 SDG 3 (72%)
Enhancing cholangiocarcinoma immunotherapy with adoptive T cells targeting HLA-restricted neoantigen peptides derived from driver gene mutations
ผู้แต่ง: Panya A.
Biomedicine and Pharmacotherapy (2023)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (RGNS 068-63)
บทคัดย่อ (Abstract): Precision immunotherapy, driven by genomic and bioinformatic advancements, has emerged as a promising and viable approach to combat cancer. Targeting neoantigens offers the advantage of specific immune responses with minimal off-tumor toxicity. In this study, we investigated the potential of adop...
scopus DOI: 10.1016/j.biopha.2023.115827 Q1 Co-Author 3 SDG 3 (97%) 9 SDG 9 (62%) RCR 0.66 · เปอร์เซ็นไทล์ 37
Efficacy and safety of nanoparticle albumin-bound paclitaxel in advanced non-small cell lung cancer: A systematic review and meta-analysis of clinical trials and observational studies
ผู้แต่ง: Suwannasom N.
Heliyon (2023)
ประเทศร่วมวิจัย: Germany, Thailand
แหล่งทุนวิจัย: University of Phayao (UoE62010)
บทคัดย่อ (Abstract): BackgroundThe efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) in advanced non-small cell lung cancer (NSCLC) have yielded inconsistent findings.Materials and methodsWe conducted a systematic review and meta-analysis, including comparative and noncomparative trials an...
scopus DOI: 10.1016/j.heliyon.2023.e21903 Q1 Co-Author 3 SDG 3 (97%) 9 SDG 9 (41%) RCR 0.43 · เปอร์เซ็นไทล์ 26
Anti-cancer effect of a phytochemical compound – 7R-acetylmelodorinol – against triple-negative breast cancer cells
ผู้แต่ง: Thepmalee C.
Biomedicine and Pharmacotherapy (2023)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (RGNS 63-145)
บทคัดย่อ (Abstract): Triple-negative breast cancer (TNBC) is a highly aggressive subtype currently lacking effective treatment options. Consequently, novel and effective drugs or compounds are urgently needed to treat TNBC. Therefore, this study aimed to evaluate the potential of 7R-acetylmelodorinol (7R-AMDL), a phy...
scopus DOI: 10.1016/j.biopha.2023.115286 Q1 First Author 3 SDG 3 (96%) 9 SDG 9 (41%) RCR 0.80 · เปอร์เซ็นไทล์ 43
Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study
ผู้แต่ง: Suwannasom N.
Beilstein Journal of Nanotechnology (2023)
ประเทศร่วมวิจัย: Germany, Thailand
แหล่งทุนวิจัย: University of Phayao (FF64-RIB006)
บทคัดย่อ (Abstract): Curcumin (CUR), a polyphenolic compound, shows promising biological properties, particularly antioxidant activity. However, its medical applications are limited due to its low water solubility, bioavailability, and pH-instability. CUR-loaded albumin microparticles (CUR-HSA-MPs) of submicron size ...
scopus DOI: 10.3762/BJNANO.14.93 Q2 Co-Author 3 SDG 3 (85%) 9 SDG 9 (40%) RCR 0.88 · เปอร์เซ็นไทล์ 46
A Review Article: Fall Incidents and Interior Architecture— Influence of Executive Function in Normal Ageing
ผู้แต่ง: Chanbenjapipu P.
Journal of Architectural Planning Research and Studies (2023)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chulalongkorn University
บทคัดย่อ (Abstract): Many ageing people are staying at home, whether they are self-isolating or social distancing, because of the current Covid-19 situation. Fall incidents at home among the ageing are significantly associated with a high level of mortality. Bathrooms are frequently reported as a major environmental ...
scopus DOI: 10.56261/jars.v20i1.249299 Q2 Co-Author 3 SDG 3 (96%) 11 SDG 11 (72%)
Evaluation of Anti-Hyperglycemia and Complications of Red and Black Thai Jasmine Rice Cultivars in Streptozotocin-Induced Diabetic Rats
ผู้แต่ง: Suwannasom N.
Molecules (2022)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (104062)
บทคัดย่อ (Abstract): The phytochemical constituents of red (RR) and black (BR) rice extracts were determined using high-pressure liquid chromatography (HPLC). Phytochemical screening revealed the presence of catechin, rutin, isoquercetin, cyanidin 3-glucoside, cyanidin 3-O-rutinoside, peonidin and quercetin. The anti...
scopus DOI: 10.3390/molecules27228043 Q1 Co-Author 3 SDG 3 (90%) 2 SDG 2 (30%) RCR 0.89 · เปอร์เซ็นไทล์ 46
Rare prenylated isoflavonoids from the young twigs of Millettia extensa and their cytotoxic activities
ผู้แต่ง: Cheenpracha S.
Rsc Advances (2022)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (FF65-RIM050)
บทคัดย่อ (Abstract): Three new isoflavonoids, millexatins N-P (1-3), along with seven known compounds (6-10), were isolated from the acetone extract of the young twigs of Millettia extensa. The structures were characterized by NMR spectroscopic and mass spectrometric analyses. Millexatin N (1) is an unusual geminal d...
scopus DOI: 10.1039/d2ra05950a Q1 Co-Author 3 SDG 3 (82%) 15 SDG 15 (45%) RCR 0.86 · เปอร์เซ็นไทล์ 45
High prevalence of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates: A 5-year retrospective study at a Tertiary Hospital in Northern Thailand
ผู้แต่ง: Siriphap A.
Frontiers in Cellular and Infection Microbiology (2022)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Otago School of Medical Sciences (MS 201003)
บทคัดย่อ (Abstract): Background: The global emergence and spread of extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales, especially Escherichia coli and Klebsiella pneumoniae, have been recognized as a public health concern as severe infections caused by these microorganisms increase morbidity and mort...
scopus DOI: 10.3389/fcimb.2022.955774 Q1 Co-Author 3 SDG 3 (90%) RCR 3.10 · เปอร์เซ็นไทล์ 85
Marginaols G–M, anti-inflammatory isopimarane diterpenoids, from the rhizomes of Kaempferia marginata
ผู้แต่ง: Chokchaisiri R.
Phytochemistry (2022)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (FF64-UoE033)
บทคัดย่อ (Abstract): Marginaols G–M, a series of undescribed isopimarane diterpenoids, together with four known analogs were isolated from the rhizomes of Kaempferia marginata. The structures of these isolated compounds were characterized using high-resolution mass spectrometry and extensive 1D- and 2D-nuclear magnet...
scopus DOI: 10.1016/j.phytochem.2022.113225 Q1 Co-Author 3 SDG 3 (90%) 15 SDG 15 (45%) RCR 1.14 · เปอร์เซ็นไทล์ 55
Effect of ethanolic extract from Piper sarmentosum on antihyperglycemic activity and complications in normal and streptozotocin-induced diabetic rats
ผู้แต่ง: Suwannasom N.
Journal of Applied Pharmaceutical Science (2022)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (FF64-RIB006)
บทคัดย่อ (Abstract): The antihyperglycemic effect of ethanolic extract of Piper sarmentosum leaves (PSE) on diabetes and its complications was evaluated in streptozotocin-induced diabetic rats. Seventy-two Wistar albino rats (n = 72) were randomly distributed into six groups (n = 12 per group), namely control, normal...
scopus DOI: 10.7324/JAPS.2022.120408 Q2 Co-Author 3 SDG 3 (95%)
Development of a Novel Anti-CD19 CAR Containing a Fully Human scFv and Three Costimulatory Domains
ผู้แต่ง: Wutti-in Y.
Frontiers in Oncology (2022)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Mahidol University (C10F630063)
บทคัดย่อ (Abstract): Second-generation anti-CD19-chimeric antigen receptor T cells (anti-CD19-CAR2 T cells) are effective for treating B-cell malignancies; however, anti-CD19-CAR2 T cells can induce human anti-mouse immune responses because anti-CD19 single-chain variable fragment (scFv) in the CAR molecules is deriv...
scopus DOI: 10.3389/fonc.2021.802876 Q1 Co-Author 3 SDG 3 (97%) 9 SDG 9 (60%) RCR 1.41 · เปอร์เซ็นไทล์ 62
Antibacterial Activity of Acorus calamus Linn. and Litsea cubeba (Lour.) Pers. and Their Efficacy in Shower Gel Formulation
ผู้แต่ง: Chaiwaree S.
Tropical Journal of Natural Product Research (2021)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: University of Phayao (UPSP-IRTC 63/005)
บทคัดย่อ (Abstract): Acorus calamus and Litsea cubeba are known to have antibacterial properties. This research aimed to evaluate the anti-acne activity of A. calamus and L. cubeba against acne bacteria and to develop a shower gel. The antibacterial activity of the extracts was assessed by disc-diffusion method. The ...
scopus DOI: 10.26538/tjnpr/v5i12.7 Q3 Co-Author 3 SDG 3 (96%) 12 SDG 12 (42%)
Suppression of TGF-β and IL-10 receptors on self-differentiated dendritic cells by short-hairpin RNAs enhanced activation of effector T-cells against cholangiocarcinoma cells
ผู้แต่ง: Thepmalee C.
Human Vaccines and Immunotherapeutics (2020)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (IRN58W0001)
บทคัดย่อ (Abstract): Cholangiocarcinoma (CCA) is an aggressive tumor that is associated with high rates of recurrence and mortality. This is due, in part, to the fact that CCA cells and their microenvironment secrete immunosuppressive cytokines, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), that in...
scopus DOI: 10.1080/21645515.2019.1701913 Q1 First Author 3 SDG 3 (95%) 9 SDG 9 (45%) RCR 0.85 · เปอร์เซ็นไทล์ 45
Endoplasmic reticulum stress, unfolded protein response and autophagy contribute to resistance to glucocorticoid treatment in human acute lymphoblastic leukaemia cells
ผู้แต่ง: Sudsaward S.
International Journal of Oncology (2020)
ประเทศร่วมวิจัย: Thailand, United Kingdom, United States, Italy
แหล่งทุนวิจัย: Thailand Research Fund (PHD/0044/2556)
บทคัดย่อ (Abstract): Acute lymphoblastic leukaemia (ALL) is the most frequent childhood cancer and, although it is highly treatable, resistance to therapy, toxicity and side effects remain challenging. The synthetic glucocorticoid (GC) dexamethasone (Dex) is commonly used to treat ALL, the main drawback of which is t...
scopus DOI: 10.3892/ijo.2020.5089 Q1 Co-Author 3 SDG 3 (95%) RCR 0.47 · เปอร์เซ็นไทล์ 28
Gemcitabine enhances cytotoxic activity of effector T-lymphocytes against chemo-resistant cholangiocarcinoma cells
ผู้แต่ง: Sawasdee N.
International Immunopharmacology (2020)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Chiang Mai University (R000018548)
บทคัดย่อ (Abstract): Cholangiocarcinoma (CCA) can resist chemotherapy resulting in treatment failure. Gemcitabine, a chemotherapeutic drug, can sensitize cancer cells to become susceptible to cytotoxic T-lymphocytes (CTLs). We, therefore, hypothesized that a combination of gemcitabine and CTLs would be more effective...
scopus DOI: 10.1016/j.intimp.2019.106006 Q1 Co-Author 3 SDG 3 (95%) RCR 1.25 · เปอร์เซ็นไทล์ 58
Cytolytic Activity of Effector T-lymphocytes Against Hepatocellular Carcinoma is Improved by Dendritic Cells Pulsed with Pooled Tumor Antigens
ผู้แต่ง: Chieochansin T.
Scientific Reports (2019)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Newton Fund (R016010006)
บทคัดย่อ (Abstract): Cellular immunotherapy is a promising new therapeutic approach for hepatocellular carcinoma (HCC), which has a high recurrence rate, irrespective of the treatment administered. In this study, we attempted to improve the cytolytic activity of effector T-lymphocytes against HCC. T-lymphocytes were ...
scopus DOI: 10.1038/s41598-019-54087-0 Q1 Co-Author 3 SDG 3 (97%) 9 SDG 9 (45%) RCR 0.46 · เปอร์เซ็นไทล์ 27
Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress
ผู้แต่ง: Garva R.
Frontiers in Oncology (2019)
ประเทศร่วมวิจัย: Australia, Thailand, United Kingdom, United States
แหล่งทุนวิจัย: Stanford University
บทคัดย่อ (Abstract): The class III NAD+ dependent deacetylases-sirtuins (SIRTs) link transcriptional regulation to DNA damage response and reactive oxygen species generation thereby modulating a wide range of cellular signaling pathways. Here, the contribution of SIRT1, SIRT3, and SIRT5 in the regulation of cellular ...
scopus DOI: 10.3389/fonc.2019.00949 Q1 Co-Author 3 SDG 3 (90%) 9 SDG 9 (40%) RCR 0.85 · เปอร์เซ็นไทล์ 45
Cytotoxic activity of effector T cells against cholangiocarcinoma is enhanced by self-differentiated monocyte-derived dendritic cells
ผู้แต่ง: Panya A.
Cancer Immunology Immunotherapy (2018)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Office of the Higher Education Commission (R016010006)
บทคัดย่อ (Abstract): Cholangiocarcinoma (CCA) is a cancer of the bile ducts that is associated with poor prognosis and poor treatment outcome. Approximately one-third of CCA patients can undergo surgery, but the recurrence rate is high and chemotherapy often cannot satisfactorily prolong survival. Cellular immunother...
scopus DOI: 10.1007/s00262-018-2212-2 Q1 Co-Author 3 SDG 3 (97%) 9 SDG 9 (45%) RCR 0.96 · เปอร์เซ็นไทล์ 49
Inhibition of IL-10 and TGF-β receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells
ผู้แต่ง: Thepmalee C.
Human Vaccines and Immunotherapeutics (2018)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Thailand Research Fund (PHD/0044/2556)
บทคัดย่อ (Abstract): Tumor escapes host immune responses by producing immunosuppressive cytokines, such as IL-10 and TGF-β, secreted into the tumor microenvironment. These cytokines play important roles in the suppression of dendritic cell (DC) function, leading to decreased immune responses of the effector CD4+ and ...
scopus DOI: 10.1080/21645515.2018.1431598 Q1 First Author 3 SDG 3 (95%) 9 SDG 9 (40%) RCR 2.76 · เปอร์เซ็นไทล์ 82
Enhanced cytotoxic activity of effector T-cells against cholangiocarcinoma by dendritic cells pulsed with pooled mRNA
ผู้แต่ง: Junking M.
Tumor Biology (2017)
ประเทศร่วมวิจัย: Thailand
แหล่งทุนวิจัย: Thailand Research Fund (IRG5980006)
บทคัดย่อ (Abstract): Cholangiocarcinoma is a malignancy of bile duct epithelia with an increasing in incidence rate worldwide. Surgery is the only curative treatment, while adjuvant chemotherapy and radiotherapy render poor responses. Cell-based immunotherapy is a potential strategy for cholangiocarcinoma treatment. ...
scopus DOI: 10.1177/1010428317733367 Q3 Co-Author 3 SDG 3 (97%) 9 SDG 9 (45%) RCR 0.74 · เปอร์เซ็นไทล์ 40
Changes in the NS1 gene of avian influenza viruses isolated in Thailand affect expression of type i interferon in primary chicken embryonic fibroblast cells
ผู้แต่ง: Thepmalee C.
Indian Journal of Virology (2013)
ประเทศร่วมวิจัย: Thailand
บทคัดย่อ (Abstract): The non-structural protein 1 (NS1) of avian influenza virus was defined as one of the virulent factors. To understand the effect of NS1 protein of influenza virus H5N1 isolated in Thailand on type I (a/b) interferon (IFN) synthesis, five reverse genetic viruses were constructed and used as models...
scopus DOI: 10.1007/s13337-013-0158-8 First Author 3 SDG 3 (90%) 2 SDG 2 (60%) RCR 0.15 · เปอร์เซ็นไทล์ 10